Liu Yanxi, Shah Karan M, Luo Jian
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Department of Oncology and Metabolism, The Medical School, The University of Sheffield, Sheffield, United Kingdom.
Front Bioeng Biotechnol. 2021 Dec 17;9:770655. doi: 10.3389/fbioe.2021.770655. eCollection 2021.
Articular cartilage is an avascular tissue, with limited ability to repair and self-renew. Defects in articular cartilage can induce debilitating degenerative joint diseases such as osteoarthritis. Currently, clinical treatments have limited ability to repair, for they often result in the formation of mechanically inferior cartilage. In this review, we discuss the factors that affect cartilage homeostasis and function, and describe the emerging regenerative approaches that are informing the future treatment options.
关节软骨是一种无血管组织，修复和自我更新能力有限。关节软骨缺损可引发骨关节炎等使人衰弱的退行性关节疾病。目前，临床治疗的修复能力有限，因为它们常常导致形成机械性能较差的软骨。在这篇综述中，我们讨论了影响软骨内环境稳定和功能的因素，并描述了为未来治疗方案提供依据的新兴再生方法。
