Physical Intelligence Department, Max Planck Institute for Intelligent Systems, 70569, Stuttgart, Germany.
Department of Mechanical and Process Engineering, ETH Zurich, CH-8092, Zurich, Switzerland.
Adv Mater. 2018 Feb;30(7). doi: 10.1002/adma.201704530. Epub 2018 Jan 8.
Wearable transdermal delivery systems have recently received tremendous attention due to their noninvasive, convenient, and prolonged administration of pharmacological agents. Here, the material prospects, fabrication processes, and drug-release mechanisms of these types of therapeutic delivery systems are critically reviewed. The latest progress in the development of multifunctional wearable devices capable of closed-loop sensation and drug delivery is also discussed. This survey reveals that wearable transdermal delivery has already made an impact in diverse healthcare applications, while several grand challenges remain.
可穿戴透皮给药系统由于其非侵入性、方便和延长药物的给药时间，最近受到了极大的关注。本文批判性地综述了这些治疗性给药系统的材料前景、制造工艺和药物释放机制。还讨论了能够进行闭环感知和药物输送的多功能可穿戴设备的最新发展进展。这项调查表明，可穿戴透皮给药已经在各种医疗保健应用中产生了影响，但仍存在一些重大挑战。
