Saqib Fatima, Usman Faisal, Malik Shehneela, Bano Naheed, Ur-Rahman Najm, Riaz Muhammad, Marc Vlaic Romina Alina, Mureşan Crina Carmen
Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60000, Pakistan.
Faculty of Veterinary and Animal Sciences, MNS-University of Agriculture, Multan 60000, Pakistan.
Plants (Basel). 2021 Dec 27;11(1):78. doi: 10.3390/plants11010078.
(D.Don) Raab-Straube is a commonly used remedy against various diseases. Crude extract and fractions of were investigated for a gastrointestinal, bronchodilator, cardiovascular, and anti-inflammatory activities. crude extract (Hh.Cr) relaxed spontaneous contractions and K (80 mM)-induced contraction in jejunum tissue dose-dependently. The relaxation of K (80 mM) indicates the presence of Ca channel blocking (CCB) effect, which was further confirmed by constructing calcium response curves (CRCs) as they caused rightward parallel shift of CRCs in a manner comparable to verapamil, so the spasmolytic effect of Hh.Cr was due to its CCB activity. Application of Hh.Cr on CCh (1 µM) and K (80 mM)-induced contraction in tracheal preparation resulted in complete relaxation, showing its bronchodilator effect mediated through Ca channels and cholinergic antagonist activity. Application of Hh.Cr on aortic preparations exhibited vasorelaxant activity through angiotensin and α-adrenergic receptors blockage. It also showed the cardio suppressant effect with negative chronotropic and inotropic response in paired atrium preparation. Similar effects were observed in in vivo models, i.e., decreased propulsive movement, wet feces, and inhibition of edema formation.
（D. 唐）拉布 - 施特劳贝是一种常用于治疗各种疾病的药物。对其粗提物及其馏分进行了胃肠道、支气管扩张、心血管和抗炎活性研究。粗提物（Hh.Cr）能剂量依赖性地松弛空肠组织的自发收缩以及钾（80 mM）诱导的收缩。钾（80 mM）诱导收缩的松弛表明存在钙通道阻滞（CCB）效应，通过构建钙反应曲线（CRC）进一步证实了这一点，因为它使CRC向右平行移动，其方式与维拉帕米相当，所以Hh.Cr的解痉作用归因于其CCB活性。将Hh.Cr应用于气管制剂中由乙酰胆碱（1 µM）和钾（80 mM）诱导的收缩，导致完全松弛，表明其支气管扩张作用是通过钙通道和胆碱能拮抗剂活性介导的。将Hh.Cr应用于主动脉制剂表现出通过血管紧张素和α - 肾上腺素能受体阻滞的血管舒张活性。在配对心房制剂中，它还表现出负性变时性和变力性反应的心脏抑制作用。在体内模型中也观察到了类似的效果，即推进运动减少、湿粪减少以及水肿形成受到抑制。
