Mitri Sara, Koubaa Mohamed, Maroun Richard G, Rossignol Tristan, Nicaud Jean-Marc, Louka Nicolas
Université de Technologie de Compiègne, ESCOM, TIMR (Integrated Transformations of Renewable Matter), Centre de Recherche Royallieu, CS 60319, CEDEX, 60203 Compiègne, France.
Laboratoire CTA, UR TVA, Centre d'Analyses et de Recherche, Faculté des Sciences, Université Saint-Joseph, Beyrouth 1104 2020, Lebanon.
Foods. 2022 Jan 1;11(1):109. doi: 10.3390/foods11010109.
Due to its pleasant rosy scent, the aromatic alcohol 2-phenylethanol (2-PE) has a huge market demand. Since this valuable compound is used in food, cosmetics and pharmaceuticals, consumers and safety regulations tend to prefer natural methods for its production rather than the synthetic ones. Natural 2-PE can be either produced through the extraction of essential oils from various flowers, including roses, hyacinths and jasmine, or through biotechnological routes. In fact, the rarity of natural 2-PE in flowers has led to the inability to satisfy the large market demand and to a high selling price. Hence, there is a need to develop a more efficient, economic, and environmentally friendly biotechnological approach as an alternative to the conventional industrial one. The most promising method is through microbial fermentation, particularly using yeasts. Numerous yeasts have the ability to produce 2-PE using l-Phe as precursor. Some agro-industrial waste and by-products have the particularity of a high nutritional value, making them suitable media for microbial growth, including the production of 2-PE through yeast fermentation. This review summarizes the biotechnological production of 2-PE through the fermentation of different yeasts on synthetic media and on various agro-industrial waste and by-products.
由于具有宜人的玫瑰香气，芳香醇2-苯乙醇（2-PE）有着巨大的市场需求。鉴于这种珍贵的化合物用于食品、化妆品和药品，消费者和安全法规倾向于采用天然方法而非合成方法来生产它。天然2-PE既可以通过从包括玫瑰、风信子和茉莉在内的各种花朵中提取精油来生产，也可以通过生物技术途径生产。事实上，花朵中天然2-PE的稀缺导致无法满足巨大的市场需求，进而使其售价高昂。因此，有必要开发一种更高效、经济且环保的生物技术方法，以替代传统的工业方法。最有前景的方法是通过微生物发酵，特别是利用酵母。许多酵母能够以L-苯丙氨酸为前体生产2-PE。一些农业工业废弃物和副产品具有高营养价值的特性，使其成为微生物生长的合适培养基，包括通过酵母发酵生产2-PE。本文综述了通过不同酵母在合成培养基以及各种农业工业废弃物和副产品上发酵生产2-PE的生物技术。
