Department of Energy, Politecnico di Milano, 20133 Milan, Italy.
Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 20133 Milan, Italy.
Molecules. 2021 Dec 22;27(1):30. doi: 10.3390/molecules27010030.
The applications of SERS in therapeutic drug monitoring, or other fields of analytical chemistry, require the availability of sensitive sensors and experimental approaches that can be implemented in affordable ways. In this contribution, we show the production of cost-effective SERS sensors obtained by depositing Lee-Meisel Ag colloids on filter paper either by natural sedimentation or centrifugation. We have characterized the morphological and plasmonic features of the sensors by optical microscopy, SEM, and UV-Vis spectroscopy. Such sensors can be used to quantify by SERS the anti-epileptic drug Perampanel (in the concentration range 1 × 10-5 × 10 M) by spinning them during the micro-Raman measurements on the top of a custom device obtained from spare part hard disk drives. This approach minimizes laser-induced heating effects and allows averaging over the spatial non-uniformity of the sensor.
SERS 在治疗药物监测或分析化学的其他领域的应用，需要能够以经济实惠的方式实现的敏感传感器和实验方法。在本贡献中，我们展示了通过将 Lee-Meisel Ag 胶体通过自然沉降或离心沉积在滤纸上来制备具有成本效益的 SERS 传感器。我们通过光学显微镜、SEM 和 UV-Vis 光谱法对传感器的形态和等离子体特征进行了表征。通过在从备用硬盘驱动器获得的定制设备的顶部进行微拉曼测量时旋转这些传感器，可以使用 SERS 来定量测定抗癫痫药物 Perampanel（浓度范围为 1×10-5×10 M）。这种方法可以最小化激光诱导的加热效应，并允许对传感器的空间不均匀性进行平均。
