Chirumbolo Salvatore, Valdenassi Luigi, Franzini Marianno, Pandolfi Sergio, Ricevuti Giovanni, Tirelli Umberto
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy.
Italian Society of Oxygen Ozone Therapy (SIOOT), University of Pavia, 27100 Pavia, Italy.
J Clin Med. 2021 Dec 29;11(1):173. doi: 10.3390/jcm11010173.
(1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a syndrome that has fatigue as its major symptom. Evidence suggests that ozone is able to relieve ME/CFS-related fatigue in affected patients. (2) Objective: To evaluate whether differences exist between males and females in ozone therapy outputs in ME/CFS. (3) Methods: In total, 200 patients previously diagnosed with ME/CFS (mean age 33 ± 13 SD years) underwent treatment with oxygen-ozone autohemotherapy (O-O-AHT). Fatigue was investigated via an FSS 7-scoring questionnaire before and following 1 month after treatment. (4) Results: The Mann-Whitney test (MW test) assessed the significance of this difference (H = 13.8041, = 0.0002), and female patients showed better outcomes than males. This difference was particularly striking in the youngest age cohort (14-29 years), and a KW test resulted in H = 7.1609, = 0.007 for the Δ = 28.3% (males = 3.8, females = 5.3). (5) Conclusions: When treated with O-O-AHT, females respond better than males.
(1) 背景：肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种以疲劳为主要症状的综合征。有证据表明，臭氧能够缓解ME/CFS患者的相关疲劳症状。(2) 目的：评估ME/CFS患者在臭氧治疗效果上是否存在性别差异。(3) 方法：总共200名先前被诊断为ME/CFS的患者（平均年龄33±13标准差岁）接受了臭氧自血疗法（O-O-AHT）治疗。在治疗前及治疗后1个月，通过疲劳严重程度量表（FSS）7分制问卷对疲劳情况进行调查。(4) 结果：曼-惠特尼检验（MW检验）评估了这种差异的显著性（H = 13.8041，P = 0.0002），女性患者的治疗效果优于男性。这种差异在最年轻的年龄组（14 - 29岁）中尤为显著，卡方检验得出H = 7.1609，P = 0.007，差值为28.3%（男性 = 3.8，女性 = 5.3）。(5) 结论：接受臭氧自血疗法治疗时，女性的反应比男性更好。
