Department of Bioengineering, University of California, Riverside, California 92521, United States.
Korea Institute of Materials Science, 797 Changwondaero, Seongsan gu, Changwon, Gyeongnam 51508, South Korea.
ACS Appl Bio Mater. 2021 Apr 19;4(4):3706-3715. doi: 10.1021/acsabm.1c00232. Epub 2021 Mar 26.
The control over biodistribution and pharmacokinetics is critical to enhance the efficacy and minimize the side effects of therapeutic agents. To address the need for an on-demand drug delivery system for precise control over the release time and the quantity of drugs, we exploited the mechano-responsiveness of piezoelectric poly(vinylidene fluoride-trifluroethylene) (P(VDF-TrFE)) nanofibers for drug delivery applications. The large surface area-to-volume ratio inherent to nanomaterials, together with the transformative piezoelectric properties, allowed us to use the material as an ultrasensitive and mechano-responsive drug delivery platform driven by the direct piezoelectric effect. The intrinsic negative zeta potential of the nanofibers was utilized to electrostatically load cationic drug molecules, where surface potential changes by exogenous mechanical actuation trigger the release of drug molecules. We show that the drug release kinetics of the P(VDF-TrFE) nanofibers depends on the fiber diameter, thus piezoelectric properties. We further demonstrated that the drug release quantity can be tuned by the applied pressure or dose of physiologically safe corporeal shockwaves as a mechanical stimulus in and models. Overall, we demonstrated the utility of piezoelectric electrospun nanofibers for mechano-responsive controlled drug release.
生物分布和药代动力学的控制对于提高治疗剂的疗效和最小化副作用至关重要。为了解决对按需药物输送系统的需求，以精确控制药物的释放时间和数量，我们利用了压电聚（偏二氟乙烯-三氟乙烯）（P（VDF-TrFE））纳米纤维的机械响应性来应用于药物输送。纳米材料固有的大表面积与体积比，加上变革性的压电特性，使我们能够将该材料用作超灵敏和机械响应性药物输送平台，该平台由直接压电效应驱动。纳米纤维的固有负 zeta 电位被用于静电加载阳离子药物分子，其中通过外部机械致动引起的表面电势变化触发药物分子的释放。我们表明，P（VDF-TrFE）纳米纤维的药物释放动力学取决于纤维直径，从而取决于压电特性。我们进一步证明，药物释放量可以通过应用压力或剂量的生理安全的体冲击波作为机械刺激来调节，在 和 模型中进行了演示。总体而言，我们证明了压电静电纺纳米纤维在机械响应控制药物释放方面的实用性。
