Zabolotneva Anastasia A, Shatova Olga P, Sadova Anastasia A, Shestopalov Aleksandr V, Roumiantsev Sergei A
N. I. Pirogov Russian National Research Medical University, 1 Ostrovitianov str., 117997 Moscow, Russia.
Center for Digital and Translational Biomedicine, Center for Molecular Health, 32 Nakhimovskiy Prospekt, 117218 Moscow, Russia.
J Nutr Metab. 2022 Jan 5;2022:4667607. doi: 10.1155/2022/4667607. eCollection 2022.
The investigation of alkylresorcinols has drawn an increasing interest recently. Alkylresorcinols (ARs) are natural chemical compounds synthesized by bacteria, fungi, sponges, and higher plants, possessing a lipophilic polyphenol structures and a myriad of biological properties. Human takes ARs as a component of a whole grain diet (from whole grain rye, wheat, and barley products), and thus, alkylresorcinols are frequently used as whole grain intake markers. Besides, ARs are considered as promising bioregulators of metabolic and immune processes, as well as adjuvant therapeutic agents for antimicrobial and anticancer treatment. In this review, we attempted to systematize the accumulated information concerning ARs origin, metabolism, biological properties, and their effect on human health.
最近，对烷基间苯二酚的研究越来越受到关注。烷基间苯二酚（ARs）是由细菌、真菌、海绵和高等植物合成的天然化合物，具有亲脂性多酚结构和多种生物学特性。人类将ARs作为全谷物饮食（来自全谷物黑麦、小麦和大麦产品）的一个组成部分，因此，烷基间苯二酚经常被用作全谷物摄入量的标志物。此外，ARs被认为是代谢和免疫过程中有前景的生物调节剂，以及抗菌和抗癌治疗的辅助治疗剂。在这篇综述中，我们试图将有关ARs的起源、代谢、生物学特性及其对人类健康影响的累积信息进行系统化整理。
