Wang Yidan, Niu Wen, Qu Xiaoyan, Lei Bo
Frontier Institute of Science and Technology, Instrument Analysis Center, Xi'an Jiaotong University, Xi'an 710054, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710054, China.
ACS Appl Mater Interfaces. 2022 Feb 2;14(4):4946-4958. doi: 10.1021/acsami.1c21082. Epub 2022 Jan 24.
Postsurgical tumor recurrence, infection, and tissue defect are still the challenges in clinical medicine. The development of multifunctional biomaterial scaffolds with a microenvironment-responsive tumor-infection therapy-tissue repair is highly desirable. Herein, we report a bioactive, injectable, adhesive, self-healing, antibacterial, and anti-inflammatory metal-polyphenol polypeptide nanocomposite scaffold (PEAPF) with temporal-spatial-controlled inflammation-triggered therapeutic properties for efficient infection and postsurgical tumor therapy and skin repair. PEAPF scaffolds showed sustained and inherent inflammation-triggered Fenton catalysis and mild thermochemical effect for specifically inhibiting tumor recurrence and . The PEAPF scaffolds significantly facilitated skin tissue regeneration in MRSA-infected chronic wounds and postsurgical tissue defects after tumor resection. This study presents the multifunctional scaffold-based safe and efficient therapeutic strategy to prevent local tumor recurrence and enhance postsurgical tissue regeneration.
术后肿瘤复发、感染和组织缺损仍是临床医学面临的挑战。开发具有微环境响应性肿瘤感染治疗 - 组织修复功能的多功能生物材料支架具有迫切需求。在此，我们报道了一种具有时空可控炎症触发治疗特性的生物活性、可注射、粘性、自愈、抗菌和抗炎的金属 - 多酚多肽纳米复合支架（PEAPF），用于高效的感染和术后肿瘤治疗以及皮肤修复。PEAPF支架表现出持续且内在的炎症触发芬顿催化和温和的热化学效应，可特异性抑制肿瘤复发。PEAPF支架显著促进了耐甲氧西林金黄色葡萄球菌感染的慢性伤口和肿瘤切除术后手术组织缺损处的皮肤组织再生。本研究提出了基于多功能支架的安全高效治疗策略，以预防局部肿瘤复发并促进术后组织再生。
