Wangpraseurt Daniel, You Shangting, Sun Yazhi, Chen Shaochen
Department of NanoEngineering, University of California San Diego, San Diego, CA, USA; Scripps Institution of Oceanography, University of California San Diego, San Diego, CA, USA.
Department of NanoEngineering, University of California San Diego, San Diego, CA, USA.
Trends Biotechnol. 2022 Jul;40(7):843-857. doi: 10.1016/j.tibtech.2022.01.003. Epub 2022 Feb 1.
3D bioprinting is currently widely used to build engineered mammalian tissue constructs with complex spatial structures. It has revolutionized tissue engineering and is a promising avenue for regenerative medicine. Recently, 3D bioprinting has also been used for the fabrication of living tissues that cultivate microorganisms including photosynthetic single-celled microalgae and bacterial cells. Here we review the principles and applications of biomimetic 3D living materials powered by microorganisms. We envision that there will be great potential for the application of microorganism-driven materials in biomedicine, biotechnology, and living device fabrication as well as for ecosystem restoration.
3D生物打印目前被广泛用于构建具有复杂空间结构的工程化哺乳动物组织构建体。它彻底改变了组织工程，是再生医学的一条有前途的途径。最近，3D生物打印也被用于制造培养包括光合单细胞微藻和细菌细胞在内的微生物的活组织。在这里，我们综述了由微生物驱动的仿生3D生物材料的原理和应用。我们设想，微生物驱动的材料在生物医学、生物技术、活体装置制造以及生态系统恢复方面将具有巨大的应用潜力。
