Shi Shuobo, Wang Zhihui, Shen Lirong, Xiao Han
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China.
Trends Biotechnol. 2022 Jul;40(7):781-803. doi: 10.1016/j.tibtech.2022.01.002. Epub 2022 Feb 1.
Concerns regarding food security arise from population growth, global warming, and reduction in arable land. With advances in synthetic biology, food production by microbes is considered to be a promising alternative that would allow rapid food production in an environmentally friendly manner. Moreover, synthetic biology can be adopted to the production of healthier or specifically designed food ingredients (e.g., high-value proteins, lipids, and vitamins) and broaden the utilization of feedstocks (e.g., methanol and CO), thereby offering potential solutions to high-quality food and the greenhouse effect. We first present how synthetic biology can facilitate the microbial production of various food components, and then discuss feedstock availability enabled by synthetic biology. Finally, we illustrate trends and key challenges in synthetic biology-driven food production.
对粮食安全的担忧源于人口增长、全球变暖和耕地减少。随着合成生物学的发展,微生物生产食品被认为是一种有前景的替代方案,能够以环境友好的方式实现快速食品生产。此外,合成生物学可应用于生产更健康或经过特殊设计的食品成分(如高价值蛋白质、脂质和维生素),并拓宽原料(如甲醇和一氧化碳)的利用范围,从而为高质量食品和温室效应提供潜在解决方案。我们首先介绍合成生物学如何促进微生物生产各种食品成分,然后讨论合成生物学带来的原料可用性。最后,我们阐述合成生物学驱动的食品生产的趋势和关键挑战。