Elbeyli Ahmet, Kurtul Bengi Ece
Department of Ophthalmology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Hatay, Turkey.
J Curr Ophthalmol. 2022 Jan 6;33(4):437-443. doi: 10.4103/joco.joco_84_21. eCollection 2021 Oct-Dec.
To investigate the influence of topical cyclopentolate 1%, as an anti-muscarinic mydriatic agent, on the peripapillary and macular microvasculature by optical coherence tomography angiography (OCT-A) in healthy adults.
A total of 41 healthy adults without any systemic or ocular disease were enrolled for this prospective consecutive study. All patients underwent OCT-A measurements (OptoVue Inc., Freemont, CA, USA) to assess optic disc status for radial peripapillary capillary network (whole image, inside disc, and peripapillary capillary densities), and superficial and deep capillary plexus whole, foveal, parafoveal and perifoveal densities, and foveal avascular zone (FAZ) densities. Foveal retinal thicknesses and all quadrant retinal fiber layer thicknesses were also assessed. The 4.5 mm × 4.5 mm peripapillary and 6 mm × 6 mm macular OCT-A images were undertaken before and 30 min after instillation of topical cyclopentolate 1% to the right eyes.
The mean age of subjects was 38.14 ± 14.10 years. All macular, optic disc, and FAZ densities, foveal retinal thicknesses, average, and all quadrant retinal fiber layer thicknesses were statistically similar between baseline and after administration of topical cyclopentolate 1% ( > 0.05).
The current study demonstrated that pupillary dilation with topical cyclopentolate 1% seems to have no statistical effect on macular and peripapillary OCT-A measurements of healthy adults.
通过光学相干断层扫描血管造影（OCT-A）研究1%环喷托酯滴眼液（一种抗毒蕈碱散瞳剂）对健康成年人视乳头周围和黄斑部微血管系统的影响。
本前瞻性连续研究共纳入41例无任何全身或眼部疾病的健康成年人。所有患者均接受OCT-A测量（美国加利福尼亚州弗里蒙特市OptoVue公司），以评估视盘状态，包括放射状视乳头周围毛细血管网络（全图、视盘内及视乳头周围毛细血管密度）、浅层和深层毛细血管丛的全层、中心凹、中心凹旁和中心凹周围密度，以及中心凹无血管区（FAZ）密度。还评估了中心凹视网膜厚度和所有象限的视网膜纤维层厚度。在右眼滴入1%环喷托酯滴眼液前及滴入后30分钟，分别采集4.5 mm×4.5 mm的视乳头周围和6 mm×6 mm的黄斑OCT-A图像。
受试者的平均年龄为38.14±14.10岁。在基线和滴入1%环喷托酯滴眼液后，所有黄斑、视盘和FAZ密度、中心凹视网膜厚度、平均值以及所有象限的视网膜纤维层厚度在统计学上均相似（P>0.05）。
本研究表明，1%环喷托酯滴眼液散瞳似乎对健康成年人的黄斑和视乳头周围OCT-A测量结果无统计学影响。
