Res Gerontol Nurs. 2022 Mar-Apr;15(2):76-84. doi: 10.3928/19404921-20220131-01. Epub 2022 Feb 11.
This secondary analysis examined (1) factors associated with willingness to participate in clinical research for cognitive health among individuals with cognitive impairment and their care partners, and (2) concordance regarding such willingness between individuals with cognitive impairment and their care partners (dyads). Neuropsychological factors and willingness to participate in clinical research were collected using self-reported questionnaires. Participants' sociodemographic and clinical information was extracted from the University of Pittsburgh Alzheimer's Disease Research Center record. Binary logistic regression and Cohen's kappa coefficient analyses were performed. Greater trust in medical researchers ( = 0.031, B = 0.127) and more severe cognitive impairment ( = 0.009, B = -0.289) were associated with willingness to participate in clinical research among individuals with cognitive impairment. Dyadic agreement on willingness to have the individual with cognitive impairment enroll in clinical research was poor to fair (κ = 0.380). Findings suggest that individuals with cognitive impairment with greater trust in health professionals are more likely to agree to clinical research participation. Nurses and other health care providers who counsel individuals with cognitive impairment and their care partners should work to build trusting relationships with participants and be mindful of how increased trust can alter power dynamics between participants and health care professionals. [(2), 76-84.].
（1）认知障碍患者及其照护者参与认知健康相关临床研究的意愿的影响因素；（2）认知障碍患者及其照护者之间（二人组）对这种参与意愿的一致性。使用自我报告问卷收集神经心理学因素和参与临床研究的意愿。参与者的社会人口统计学和临床信息从匹兹堡大学阿尔茨海默病研究中心的记录中提取。进行了二元逻辑回归和 Cohen's kappa 系数分析。对医疗研究人员的信任度更高（ = 0.031，B = 0.127）和认知障碍更严重（ = 0.009，B = -0.289）与认知障碍患者参与临床研究的意愿相关。个体与认知障碍者参与临床研究的意愿的双变量一致性为差到中等（κ = 0.380）。研究结果表明，对卫生专业人员信任度更高的认知障碍患者更有可能同意参与临床研究。为认知障碍患者及其照护者提供咨询的护士和其他医疗保健提供者应努力与参与者建立信任关系，并注意增加信任如何改变参与者与医疗保健专业人员之间的权力动态。 [(2), 76-84.]。
