Infectious Disease Prevention and Control Section, Shandong Center for Disease Control and Prevention, Jinan, China.
Infectious Disease Prevention and Control Section, School of Public Health and Health Management, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Front Cell Infect Microbiol. 2022 Feb 3;11:821828. doi: 10.3389/fcimb.2021.821828. eCollection 2021.
The urgent approval of the use of the inactivated COVID-19 vaccine is essential to reduce the threat and burden of the epidemic on global public health, however, our current understanding of the host immune response to inactivated vaccine remains limited. Herein, we performed serum IgG antibody detection and transcriptomics analysis on 20 SARS-CoV-2 naïve individuals who received multiple doses of inactivated vaccine and 5 SARS-CoV-2 recovered individuals who received single dose of inactivated vaccine. Our research revealed the important role of many innate immune pathways after vaccination, identified a significant correlation with the third dose of booster vaccine and proteasome-related genes, and found that SARS-CoV-2 recovered individuals can produces a strong immune response to a single dose of inactivated vaccine. These results help us understand the reaction mechanism of the host's molecular immune system to the inactivated vaccine, and provide a basis for the choice of vaccination strategy.
紧急批准使用新冠灭活疫苗对于减轻全球公共卫生领域的疫情威胁和负担至关重要，然而，我们目前对于人体对灭活疫苗的免疫反应的理解仍有限。在此，我们对 20 名从未感染过 SARS-CoV-2 的个体（他们接受了多剂灭活疫苗）和 5 名曾感染过 SARS-CoV-2 的个体（他们接受了一剂灭活疫苗）进行了血清 IgG 抗体检测和转录组学分析。我们的研究揭示了接种疫苗后许多固有免疫途径的重要作用，发现与第三剂加强疫苗和蛋白酶体相关基因有显著相关性，并发现已感染 SARS-CoV-2 的个体可以对一剂灭活疫苗产生强烈的免疫反应。这些结果有助于我们了解宿主分子免疫系统对灭活疫苗的反应机制，并为疫苗接种策略的选择提供依据。
