1st Department of Internal Medicine, Medical Faculty of P. J. Šafarik University, Košice, Slovakia.
Physiol Res. 2021 Dec 30;70(Suppl4):S635-S641. doi: 10.33549/physiolres.934708.
Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular diseases, including insulin resistance, diabetes mellitus type 2, obesity, hypertension, and dyslipidaemia. Many studies have assessed the role of adipokines in the etiopathogenesis of PCOS, however, no single biomarker has been recognized to be in causal relation to the syndrome. Apelin has been identified as a new adipokine linked to obesity and insulin resistance. Some studies demonstrated that the apelin / apelin receptor could play a pivotal role in the pathogenesis of polycystic ovary syndrome, however the other yielded controversial results. Underlying mechanisms of possible involvement of apelin/apelin receptor complex are discussed.
多囊卵巢综合征（PCOS）与心血管疾病的多种危险因素相关，包括胰岛素抵抗、2 型糖尿病、肥胖、高血压和血脂异常。许多研究评估了脂肪因子在 PCOS 发病机制中的作用，然而，没有单一的生物标志物被认为与该综合征有因果关系。Apelin 已被确定为一种与肥胖和胰岛素抵抗相关的新型脂肪因子。一些研究表明，apelin/apelin 受体可能在多囊卵巢综合征的发病机制中发挥关键作用，但其他研究结果则存在争议。本文讨论了 apelin/apelin 受体复合物可能参与的潜在机制。
