病理条件下线粒体生物能量学受损。
Impaired Mitochondrial Bioenergetics under Pathological Conditions.
作者信息
Nesci Salvatore, Lenaz Giorgio
机构信息
Department of Veterinary Medical Sciences, Alma Mater Studiorum University of Bologna, Via Tolara di Sopra, 50, 40064 Ozzano Emilia, BO, Italy.
Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Via Massarenti 9, Pad 11, 40138 Bologna, BO, Italy.
出版信息
Life (Basel). 2022 Jan 29;12(2):205. doi: 10.3390/life12020205.
Abstract
Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in various diseases [...].
摘要
线粒体是细胞的动力源；然而，线粒体功能障碍会导致能量耗竭，并在各种疾病中引发细胞死亡[...]。
相似文献
1
Impaired Mitochondrial Bioenergetics under Pathological Conditions.病理条件下线粒体生物能量学受损。
Life (Basel). 2022 Jan 29;12(2):205. doi: 10.3390/life12020205.
2
Mitochondrial biogenesis: pharmacological approaches.线粒体生物合成：药理学方法。
Curr Pharm Des. 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118.
3
Mitochondrial Transfer Improves Cardiomyocyte Bioenergetics and Viability in Male Rats Exposed to Pregestational Diabetes.线粒体转移改善了孕前糖尿病雄性大鼠心肌细胞的生物能量和活力。
Int J Mol Sci. 2021 Feb 27;22(5):2382. doi: 10.3390/ijms22052382.
4
Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy.左心室线粒体生物能量学的损伤先于杜氏肌营养不良症明显的心脏功能障碍和重塑。
J Physiol. 2020 Apr;598(7):1377-1392. doi: 10.1113/JP277306. Epub 2019 Feb 27.
5
Understanding D-Ribose and Mitochondrial Function.了解D-核糖与线粒体功能
Adv Biosci Clin Med. 2018;6(1):1-5. doi: 10.7575/aiac.abcmed.v.6n.1p.1.
6
Mitochondrial Transfer from Wharton's Jelly Mesenchymal Stem Cell to MERRF Cybrid Reduces Oxidative Stress and Improves Mitochondrial Bioenergetics.从沃顿胶间充质干细胞向肌阵挛性癫痫伴破碎红纤维综合征（MERRF）细胞杂交体的线粒体转移可减轻氧化应激并改善线粒体生物能量学。
Oxid Med Cell Longev. 2017;2017:5691215. doi: 10.1155/2017/5691215. Epub 2017 May 4.
7
Toxicity of brominated flame retardants, BDE-47 and BDE-99 stems from impaired mitochondrial bioenergetics.溴化阻燃剂BDE - 47和BDE - 99的毒性源于线粒体生物能量学受损。
Toxicol Mech Methods. 2015 Jan;25(1):34-41. doi: 10.3109/15376516.2014.974233. Epub 2014 Oct 30.
8
Integrated computational model of the bioenergetics of isolated lung mitochondria.孤立肺线粒体生物能量学的综合计算模型。
PLoS One. 2018 Jun 11;13(6):e0197921. doi: 10.1371/journal.pone.0197921. eCollection 2018.
9
Metabolic regulation of mitochondrial dynamics.线粒体动力学的代谢调控
J Cell Biol. 2016 Feb 15;212(4):379-87. doi: 10.1083/jcb.201511036. Epub 2016 Feb 8.
10
Mitochondrial bioenergetics and pulmonary dysfunction: Current progress and future directions.线粒体生物能量学与肺功能障碍：当前进展与未来方向
Paediatr Respir Rev. 2020 Apr;34:37-45. doi: 10.1016/j.prrv.2019.04.001. Epub 2019 Apr 12.
引用本文的文献
1
Metformin Reduces Oxidative Damage in RNASEH2-Mutant Aicardi-Goutières Cells.二甲双胍可减轻RNASEH2突变的Aicardi-Goutières综合征细胞中的氧化损伤。
Genes (Basel). 2025 Jul 30;16(8):922. doi: 10.3390/genes16080922.
2
Targeted Metabolomics Highlights Dramatic Antioxidant Depletion, Increased Oxidative/Nitrosative Stress and Altered Purine and Pyrimidine Concentrations in Serum of Primary Myelofibrosis Patients.靶向代谢组学揭示原发性骨髓纤维化患者血清中抗氧化剂显著消耗、氧化/亚硝化应激增加以及嘌呤和嘧啶浓度改变。
Antioxidants (Basel). 2024 Apr 19;13(4):490. doi: 10.3390/antiox13040490.
3
Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction.线粒体功能障碍和肝细胞凋亡通过氧化应激、翻译后修饰、炎症和肠道屏障功能障碍在肝脏疾病中的作用。
Cell Mol Life Sci. 2024 Jan 12;81(1):34. doi: 10.1007/s00018-023-05061-7.
4
The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state.线粒体钙单向转运蛋白（MCU）通过调节线粒体氧化还原状态激活线粒体呼吸并增强其迁移能力。
Redox Biol. 2023 Aug;64:102759. doi: 10.1016/j.redox.2023.102759. Epub 2023 Jun 4.
5
Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust.炎症、线粒体和天然化合物在信任循环中共存。
Int J Mol Sci. 2023 Mar 24;24(7):6106. doi: 10.3390/ijms24076106.
本文引用的文献
1
Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives.利用人类样本评估线粒体生物能量学：金标准、局限性及未来展望
Life (Basel). 2021 Sep 10;11(9):949. doi: 10.3390/life11090949.
2
In Vitro Assays for the Assessment of Impaired Mitochondrial Bioenergetics in Equine Atypical Myopathy.用于评估马属动物非典型肌病中线粒体生物能量学受损的体外分析方法。
Life (Basel). 2021 Jul 20;11(7):719. doi: 10.3390/life11070719.
3
Accessory Subunits of the Matrix Arm of Mitochondrial Complex I with a Focus on Subunit NDUFS4 and Its Role in Complex I Function and Assembly.线粒体复合物I基质臂的辅助亚基，重点关注亚基NDUFS4及其在复合物I功能和组装中的作用
Life (Basel). 2021 May 19;11(5):455. doi: 10.3390/life11050455.
4
Mitochondrial Bioenergetics and Dynamism in the Failing Heart.衰竭心脏中的线粒体生物能量学与动态变化
Life (Basel). 2021 May 12;11(5):436. doi: 10.3390/life11050436.
5
Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration.线粒体蛋白导入与呼吸复合体组装在神经元健康和退化中的相互作用。
Life (Basel). 2021 May 11;11(5):432. doi: 10.3390/life11050432.
6
The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology.脂氧化损伤在与阿尔茨海默病病理相关的线粒体生物能量功能障碍中的因果作用。
Life (Basel). 2021 Apr 25;11(5):388. doi: 10.3390/life11050388.
7
Organization of the Respiratory Supercomplexes in Cells with Defective Complex III: Structural Features and Metabolic Consequences.细胞中细胞色素bc1复合体缺陷时呼吸超复合体的组织：结构特征与代谢后果
Life (Basel). 2021 Apr 17;11(4):351. doi: 10.3390/life11040351.
8
Mitochondrial Dynamics, ROS, and Cell Signaling: A Blended Overview.线粒体动力学、活性氧与细胞信号传导：综合概述
Life (Basel). 2021 Apr 10;11(4):332. doi: 10.3390/life11040332.
9
The ATP Synthase Deficiency in Human Diseases.人类疾病中的ATP合酶缺乏症
Life (Basel). 2021 Apr 8;11(4):325. doi: 10.3390/life11040325.
10
Molecular and Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System: Implications for Pathology.线粒体氧化磷酸化系统的分子与超分子结构：对病理学的启示
Life (Basel). 2021 Mar 15;11(3):242. doi: 10.3390/life11030242.
Zotero 插件