School of Public Health, Medical College of Soochow University, 199 Ren Ai Road, Suzhou, 215123, China.
Department of Ophthalmology, the First Affiliated Hospital of Dali University, Dali, China.
Graefes Arch Clin Exp Ophthalmol. 2024 Jan;262(1):121-132. doi: 10.1007/s00417-023-06164-4. Epub 2023 Jul 4.
To assess the associations of corneal biomechanical properties as measured by the Corvis ST with refractive errors and ocular biometry in an unselected sample of young adults.
A total of 1645 healthy university students underwent corneal biomechanical parameters measurement by the Corvis ST. The refractive status of the participants was measured using an autorefractor without cycloplegia. Ocular biometric parameters were measured using the IOL Master.
After adjusting for the effect of age, sex, biomechanical-corrected intraocular pressure and central corneal thickness, axial length was significantly associated with A1 velocity (A1v, β = -10.47), A2 velocity (A2v, β = 4.66), A2 deflection amplitude (A2DeflA, β = -6.02), HC deflection amplitude (HC-DeflA, β = 5.95), HC peak distance (HC-PD, β = 2.57), deformation amplitude ratio max (DA Rmax, β = -0.36), Ambrósio's relational thickness to the horizontal profile (ARTh, β = 0.002). For axial length / corneal radius ratio, only A1v (β = -2.01), A1 deflection amplitude (A1DeflA, β = 2.30), HC-DeflA (β = 1.49), HC-PD (β = -0.21), DA Rmax (β = 0.07), stress-strain index (SSI, β = -0.29), ARTh (β < 0.001) were significant associates. A1v (β = 23.18), HC-DeflA (β = -15.36), HC-PD (β = 1.27), DA Rmax (β = -0.66), SSI (β = 3.53), ARTh (β = -0.02) were significantly associated with spherical equivalent.
Myopic eyes were more likely to have more deformable corneas and corneas in high myopia were easier to deform and were even softer compared with those in the mild/moderate myopia.
评估 Corvis ST 测量的角膜生物力学特性与未经选择的年轻成年人屈光不正和眼生物测量之间的相关性。
共有 1645 名健康大学生接受 Corvis ST 角膜生物力学参数测量。参与者的屈光状态使用无需散瞳的自动屈光仪进行测量。眼生物测量参数使用 IOL Master 进行测量。
在调整年龄、性别、生物力学校正眼压和中央角膜厚度的影响后，眼轴与 A1 速度（A1v，β=−10.47）、A2 速度（A2v，β=4.66）、A2 挠度振幅（A2DeflA，β=−6.02）、HC 挠度振幅（HC-DeflA，β=5.95）、HC 峰距（HC-PD，β=2.57）、变形振幅比最大值（DA Rmax，β=−0.36）、Ambrósio 水平轮廓相关厚度（ARTh，β=0.002）呈显著负相关。对于眼轴/角膜半径比，仅 A1v（β=−2.01）、A1 挠度振幅（A1DeflA，β=2.30）、HC-DeflA（β=1.49）、HC-PD（β=−0.21）、DA Rmax（β=0.07）、应变-应变指数（SSI，β=−0.29）、ARTh（β<0.001）与 A1v（β=23.18）、HC-DeflA（β=−15.36）、HC-PD（β=1.27）、DA Rmax（β=−0.66）、SSI（β=3.53）、ARTh（β=−0.02）与等效球镜呈显著相关。
近视眼的角膜更具可变形性，高度近视的角膜更容易变形，甚至比轻度/中度近视的角膜更软。
