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富锌对大鼠生长繁殖的影响。

Effects of Zn-Enriched on the Growth and Reproduction of Rats.

机构信息

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

出版信息

Nutrients. 2022 Feb 13;14(4):783. doi: 10.3390/nu14040783.

DOI:10.3390/nu14040783
PMID:35215433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8878668/
Abstract

Zn is an essential trace element required for maintaining normal growth and development. Zn deficiency can cause growth retardation and reproductive system dysplasia, while Zn supplementation for treating Zn deficiency requires the use of high-quality Zn preparations. In this study, CCFM1195 was screened for its high Zn enrichment capacity, and the effects of different Zn supplementation regimens and doses on the growth and development of rats after Zn supplementation were investigated by supplementing Zn-deficient rat pups with different doses of various Zn supplements (ZnO, CCFM1195 + ZnO, and Zn-enriched CCFM1195). It was shown that the bioavailability of Zn was positively correlated with indicators of recovery after Zn supplementation, with Zn-enriched CCFM1195 having the best effect, followed by CCFM1195 + ZnO, while ZnO had the worst effect. Significant differences were also observed between the gut microbiota of control, model, and Zn-supplemented rats. Overall, administration of Zn-enriched CCFM1195 was more effective than the other approaches in restoring physical indicators of Zn deficiency after Zn supplementation, and this advantage was more significant at low-dose Zn supplementation.

摘要

锌是维持正常生长发育所必需的微量元素。锌缺乏可导致生长迟缓、生殖系统发育不良，而治疗锌缺乏的补锌则需要使用高质量的锌制剂。本研究筛选了 CCFM1195 具有较高的锌富集能力，并通过补充不同剂量的各种锌补充剂（氧化锌、CCFM1195+氧化锌和富锌 CCFM1195）来补充缺锌幼鼠，研究了不同锌补充方案和剂量对补锌后大鼠生长发育的影响。结果表明，锌的生物利用度与补锌后恢复的指标呈正相关，富锌 CCFM1195 的效果最好，其次是 CCFM1195+氧化锌，而氧化锌的效果最差。补充锌后，对照组、模型组和补锌组大鼠的肠道微生物群也存在显著差异。总的来说，补锌后，给予富锌 CCFM1195 比其他方法更能有效恢复缺锌的生理指标，且在低剂量补锌时优势更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/3db518c8d1cc/nutrients-14-00783-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/75012484e98a/nutrients-14-00783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/f42f9a4a632a/nutrients-14-00783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/a0edb7026086/nutrients-14-00783-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/e95b1ef15b1b/nutrients-14-00783-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/f5a5db09017f/nutrients-14-00783-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/95bdd8a0d299/nutrients-14-00783-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/03eae89083cb/nutrients-14-00783-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/3db518c8d1cc/nutrients-14-00783-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/75012484e98a/nutrients-14-00783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/f42f9a4a632a/nutrients-14-00783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/a0edb7026086/nutrients-14-00783-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/e95b1ef15b1b/nutrients-14-00783-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/f5a5db09017f/nutrients-14-00783-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/95bdd8a0d299/nutrients-14-00783-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/03eae89083cb/nutrients-14-00783-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e5/8878668/3db518c8d1cc/nutrients-14-00783-g008a.jpg

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