Forest Valérie, Pourchez Jérémie
Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, Etablissement Français du Sang, INSERM, U1059 Sainbiose, Centre CIS, F-42023 Saint-Etienne, France.
Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, Etablissement Français du Sang, INSERM, U1059 Sainbiose, Centre CIS, F-42023 Saint-Etienne, France.
Adv Drug Deliv Rev. 2022 Apr;183:114173. doi: 10.1016/j.addr.2022.114173. Epub 2022 Feb 22.
Respiratory diseases gather a wide range of disorders which are generally difficult to treat, partly due to a poor delivery of drugs to the lung with adequate dose and minimum side effects. With the recent developments of nanotechnology, nano-delivery systems have raised interest. In this review, we detail the main types of nanocarriers that have been developed presenting their respective advantages and limitations. We also discuss the route of administration (systemic versus by inhalation), also considering technical aspects (different types of aerosol devices) with concrete examples of applications. Finally, we propose some perspectives of development in the field such as the nano-in-micro approaches, the emergence of drug vaping to generate airborne carriers in the submicron size range, the development of innovative respiratory models to assess regional aerosol deposition of nanoparticles or the application of nano-delivery to the lung in the treatment of other diseases.
呼吸系统疾病涵盖了广泛的病症，通常难以治疗，部分原因是难以将药物以足够的剂量并最小化副作用的方式递送至肺部。随着纳米技术的最新发展，纳米递送系统引起了人们的关注。在本综述中，我们详细介绍了已开发的主要类型的纳米载体，阐述了它们各自的优点和局限性。我们还讨论了给药途径（全身给药与吸入给药），同时结合具体应用实例考虑技术方面（不同类型的雾化装置）。最后，我们提出了该领域的一些发展前景，例如纳米包微米技术、通过药物雾化产生亚微米尺寸范围的空气传播载体、开发用于评估纳米颗粒区域气溶胶沉积的创新呼吸模型，或纳米递送在肺部治疗其他疾病中的应用。
