Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, 33 Ursula Franklin Street, Toronto, Ontario M5S 2S1, Canada.
Epidemiology Division, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 1P8, Canada.
Alcohol Alcohol. 2022 Jul 9;57(4):500-507. doi: 10.1093/alcalc/agac003.
To examine how standard analytical approaches to model mortality outcomes of alcohol use compare to the true results using the impact of the March 2017 alcohol taxation increase in Lithuania on all-cause mortality as an example.
Four methodologies were used: two direct methodologies: (a) interrupted time-series on mortality and (b) comparing predictions based on time-series modeling with the real number of deaths for the year following the implementation of the tax increase; and two indirect methodologies: (c) combining a regression-based estimate for the impact of taxation on alcohol consumption with attributable-fraction methodology and (d) using price elasticities from meta-analyses to estimate the impact on alcohol consumption before applying attributable-fraction methodology.
While all methodologies estimated reductions in all-cause mortality, especially for men, there was substantial variability in the level of mortality reductions predicted. The indirect methodologies had lower predictions as the meta-analyses on elasticities and risk relations seem to underestimate the true values for Lithuania. Directly estimated effects of taxation based on the actual mortalities seem to best represent the true reductions in alcohol-attributable mortality. A significant increase in alcohol excise taxation had a marked impact on all-cause mortality in Lithuania.
以立陶宛 2017 年 3 月提高酒精税对全因死亡率的影响为例,研究标准分析方法对酒精使用死亡率结果的模拟与真实结果相比如何。
使用了四种方法:两种直接方法:(a)死亡率的中断时间序列和(b)基于时间序列建模的预测与税收增加实施后一年实际死亡人数的比较;两种间接方法:(c)将税收对酒精消费影响的回归估计与归因分数方法相结合,以及(d)在应用归因分数方法之前使用荟萃分析中的价格弹性来估计对酒精消费的影响。
虽然所有方法都估计了全因死亡率的降低,特别是男性,但预测的死亡率降低水平存在很大差异。间接方法的预测值较低,因为关于弹性和风险关系的荟萃分析似乎低估了立陶宛的真实值。基于实际死亡率直接估计的税收效应似乎最能代表酒精相关死亡率的真实降低。大幅提高酒精消费税对立陶宛的全因死亡率产生了显著影响。