Department of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA.
Adv Exp Med Biol. 2022;1363:179-183. doi: 10.1007/978-3-030-92034-0_10.
Until somewhat recently, the complexity of the human genome has not been well understood. With advancements in sequencing technology, we now know that nearly the whole genome is transcribed but a very small portion of those transcripts code for proteins. As the research of non-coding genes and transcripts has evolved rapidly in the last decade, it has become clear that many of them serve important biological functions in many previously well-studied cell processes. As the previous chapters in this book have reviewed, the field of noncoding RNA research has provided new insights into specific disease states, especially those driven by inflammation. Understanding the basic mechanisms of non-coding RNAs in the context of inflammation has led to prospective therapeutics that may overcome many of the challenges faced in diagnosing and treating inflammatory diseases. In this final chapter we discuss the current state of the field of non-coding RNA therapeutics and how it may evolve to overcome the short cummings we currently face with diagnosing and treating inflammatory diseases.
直到最近，人类基因组的复杂性还没有得到很好的理解。随着测序技术的进步，我们现在知道，几乎整个基因组都被转录，但这些转录物中只有很小一部分编码蛋白质。随着过去十年中非编码基因和转录本的研究迅速发展，人们已经清楚地认识到，其中许多基因在许多以前研究得很好的细胞过程中发挥着重要的生物学功能。正如本书前几章所回顾的，非编码 RNA 研究领域为特定疾病状态提供了新的见解，尤其是那些由炎症驱动的疾病状态。在炎症背景下理解非编码 RNA 的基本机制，导致了有前景的治疗方法，这些方法可能克服在诊断和治疗炎症性疾病方面面临的许多挑战。在最后一章中，我们讨论了非编码 RNA 治疗学的现状，以及它如何发展以克服我们目前在诊断和治疗炎症性疾病方面面临的局限性。
