Zeng Ning, Chen Xue, Liu Zeming
Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Chem. 2022 Feb 10;10:819969. doi: 10.3389/fchem.2022.819969. eCollection 2022.
Coronavirus disease 2019 (COVID-19) is a new and severe infectious disease and new global disaster and is spreading rapidly worldwide. Natural products have a long history and have been widely used to treat various acute, chronic, and even life-threatening diseases worldwide. However, the natural products have reduced bioavailability and availability as they have poor kinetic properties, such as large molecular weight, inability to cross lipid membranes, and weak absorption ability. With the rapid development of nanotechnology, using novel nanotechnology in conjunction with natural products can effectively eliminate the molecular restriction of the entry of nanoproducts into the body and can be used to diagnose and treat various diseases, including COVID-19, bringing new strategies and directions for medicine. This article reviews the role and implementation of natural products against COVID-19 based on nanotechnology.
2019冠状病毒病（COVID-19）是一种新型严重传染病和新的全球灾难，正在全球迅速蔓延。天然产物历史悠久，在世界范围内已被广泛用于治疗各种急性、慢性甚至危及生命的疾病。然而，天然产物具有较差的动力学性质，如分子量较大、无法穿过脂质膜以及吸收能力较弱，导致其生物利用度和可得性降低。随着纳米技术的迅速发展，将新型纳米技术与天然产物结合使用可以有效消除纳米产品进入体内的分子限制，并可用于诊断和治疗包括COVID-19在内的各种疾病，为医学带来新的策略和方向。本文综述了基于纳米技术的天然产物在对抗COVID-19中的作用及应用。
