Department of Pathology, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
ENT and Head and Neck Research Center and Department, Firoozgar General Hospital, The Five Senses Health Institute, Iran.
Biomed Pharmacother. 2022 Apr;148:112760. doi: 10.1016/j.biopha.2022.112760. Epub 2022 Feb 25.
Glioblastoma (GB) is a highly aggressive cancer of the central nervous system, occurring in the brain or spinal cord. Many factors such as angiogenesis are associated with GB development. Angiogenesis is a procedure by which the pre-existing blood vessels create new vessels that play an essential role in health and disease, including tumors. Also, angiogenesis is one of the significant factors thought to be responsible for treatment resistance in many tumors, including GB. Hence, an improved understanding of the molecular processes underlying GB angiogenesis will pave the way for developing potential new treatments. Recently, it has been found that microRNAs (miRNAs) and exosomal miRNAs have a crucial role in inducing or inhibiting the angiogenesis process in GB development. A better knowledge of the miRNA's regulation pathway in the angiogenesis process in cancer offers unique mechanistic insight into the mechanism of tumor-associated neovascularization. Because of advancements in miRNA characterization and delivery methods, miRNAs can also be employed in clinical settings as potential biomarkers for anti-angiogenic treatment response as well as therapies targeting tumor angiogenesis. The recent finding and insights about miRNAs' angioregulatory role and exosomal miRNAs in GB are provided throughout the review. Also, we discuss the new concept of miRNAs-based therapies for GB in the future.
胶质母细胞瘤（GB）是一种高度侵袭性的中枢神经系统癌症，发生在大脑或脊髓中。许多因素，如血管生成，与 GB 的发展有关。血管生成是一种使预先存在的血管生成新血管的过程，在健康和疾病中起着重要作用，包括肿瘤。此外，血管生成被认为是许多肿瘤包括 GB 治疗耐药的重要因素之一。因此，对 GB 血管生成的分子过程有更深入的了解，将为开发潜在的新治疗方法铺平道路。最近，人们发现 microRNAs（miRNAs）和外泌体 miRNAs 在诱导或抑制 GB 发展中的血管生成过程中起着关键作用。对 miRNA 在癌症血管生成过程中的调控途径有了更好的了解，为肿瘤相关新生血管形成的机制提供了独特的机制见解。由于 miRNA 特征和传递方法的进步，miRNAs 也可以在临床环境中用作抗血管生成治疗反应以及针对肿瘤血管生成的治疗的潜在生物标志物。本综述介绍了关于 miRNAs 在 GB 中的血管调节作用和外泌体 miRNAs 的最新发现和见解。此外，我们还讨论了未来基于 miRNAs 的治疗 GB 的新概念。
