Department of Anatomy, Brain Korea 21 Plus Program for Biomedical Science, Korea University College of Medicine, Seoul 02841, Korea.
Mol Cells. 2022 Feb 28;45(2):53-64. doi: 10.14348/molcells.2022.2019.
Three-dimensional cultures of human neural tissue/organlike structures can be achieved by mimicking the developmental processes occurring . Rapid progress in the field of neural organoids has fueled the hope (and hype) for improved understanding of brain development and functions, modeling of neural diseases, discovery of new drugs, and supply of surrogate sources of transplantation. In this short review, we summarize the state-of-the-art applications of this fascinating tool in various research fields and discuss the reality of the technique hoping that the current limitations will soon be overcome by the efforts of ingenious researchers.
通过模拟发生的发育过程，可以实现人类神经组织/类器官结构的三维培养。神经类器官领域的快速发展燃起了人们对以下方面的希望（和炒作）：深入理解大脑发育和功能、神经疾病建模、新药发现以及替代移植来源的供应。在这篇简短的综述中，我们总结了该迷人工具在各个研究领域的最新应用，并讨论了该技术的实际情况，希望有创造力的研究人员的努力能尽快克服当前的局限性。
