Zhang Chengyuan, Zhou Xuemei, Zhang Hanyi, Han Xuanliang, Li Baijun, Yang Ran, Zhou Xing
School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing, China.
Front Pharmacol. 2022 Feb 14;13:776895. doi: 10.3389/fphar.2022.776895. eCollection 2022.
Multidrug resistance (MDR) of tumors is one of the clinical direct reasons for chemotherapy failure. MDR directly leads to tumor recurrence and metastasis, with extremely grievous mortality. Engineering a novel nano-delivery system for the treatment of MDR tumors has become an important part of nanotechnology. Herein, this review will take those different mechanisms of MDR as the classification standards and systematically summarize the advances in nanotechnology targeting different mechanisms of MDR in recent years. However, it still needs to be seriously considered that there are still some thorny problems in the application of the nano-delivery system against MDR tumors, including the excessive utilization of carrier materials, low drug-loading capacity, relatively narrow targeting mechanism, and so on. It is hoped that through the continuous development of nanotechnology, nano-delivery systems with more universal uses and a simpler preparation process can be obtained, for achieving the goal of defeating cancer MDR and accelerating clinical transformation.
肿瘤的多药耐药性（MDR）是化疗失败的临床直接原因之一。MDR直接导致肿瘤复发和转移，死亡率极高。构建用于治疗MDR肿瘤的新型纳米递送系统已成为纳米技术的重要组成部分。在此，本综述将以MDR的不同机制作为分类标准，系统总结近年来针对MDR不同机制的纳米技术进展。然而，仍需认真考虑的是，纳米递送系统在对抗MDR肿瘤的应用中仍存在一些棘手问题，包括载体材料过度使用、载药量低、靶向机制相对狭窄等。希望通过纳米技术的不断发展，能够获得用途更广泛、制备过程更简单的纳米递送系统，以实现战胜癌症MDR并加速临床转化的目标。
