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从巴西非人类灵长类动物中分离出的具有不同基因组特征的黄热病毒的生物学特性

Biological Characterization of Yellow Fever Viruses Isolated From Non-human Primates in Brazil With Distinct Genomic Landscapes.

作者信息

Furtado Nathália Dias, Raphael Lidiane de Menezes, Ribeiro Ieda Pereira, de Mello Iasmim Silva, Fernandes Déberli Ruiz, Gómez Mariela Martínez, Dos Santos Alexandre Araújo Cunha, Nogueira Mônica da Silva, de Castro Márcia Gonçalves, de Abreu Filipe Vieira Santos, Martins Lívia Carício, Vasconcelos Pedro Fernando da Costa, Lourenço-de-Oliveira Ricardo, Bonaldo Myrna Cristina

机构信息

Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz/Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.

出版信息

Front Microbiol. 2022 Feb 14;13:757084. doi: 10.3389/fmicb.2022.757084. eCollection 2022.

DOI:10.3389/fmicb.2022.757084
PMID:35237244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8882863/
Abstract

Since the beginning of the XXI Century, the yellow fever virus (YFV) has been cyclically spreading from the Amazon basin to Brazil's South and Southeast regions, culminating in an unprecedented outbreak that started in 2016. In this work, we studied four YFV isolated from non-human primates obtained during outbreaks in the states of Rio Grande do Sul in 2008 (PR4408), Goiás (GO05), and Espírito Santo (ES-504) in 2017, and Rio de Janeiro (RJ 155) in 2019. These isolates have genomic differences mainly distributed in non-structural proteins. We compared the isolates' rates of infection in mammal and mosquito cells and neurovirulence in adult mice. RJ 155 and PR4408 YFV isolates exhibited higher infectivity in mammalian cells and neurovirulence in mice. In mosquito Aag2 cells, GO05 and PR4408 displayed the lowest proliferation rates. These results suggest that RJ 155 and PR4408 YFV isolates carry some genomic markers that increase infectivity in mammal hosts. From this characterization, it is possible to contribute to discovering new molecular markers for the virulence of YFV.

摘要

自21世纪初以来，黄热病病毒（YFV）一直在从亚马逊盆地周期性地传播到巴西南部和东南部地区，最终在2016年引发了一场前所未有的疫情。在这项研究中，我们研究了从2008年南里奥格兰德州（PR4408）、2017年戈亚斯州（GO05）和圣埃斯皮里图州（ES - 504）以及2019年里约热内卢州（RJ 155）疫情期间获得的非人类灵长类动物中分离出的四种YFV。这些分离株的基因组差异主要分布在非结构蛋白中。我们比较了这些分离株在哺乳动物和蚊子细胞中的感染率以及在成年小鼠中的神经毒力。RJ 155和PR4408 YFV分离株在哺乳动物细胞中表现出更高的感染性，在小鼠中表现出更高的神经毒力。在蚊子Aag2细胞中，GO05和PR4408的增殖率最低。这些结果表明，RJ 1和PR4408 YFV分离株携带一些基因组标记，这些标记增加了在哺乳动物宿主中的感染性。基于这一特征，有可能为发现黄热病病毒毒力的新分子标记做出贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/5cbccf424048/fmicb-13-757084-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/5119c5b40a64/fmicb-13-757084-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/6044a76949b0/fmicb-13-757084-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/70e4c4ece036/fmicb-13-757084-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/ca3b4d7a6912/fmicb-13-757084-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/5cbccf424048/fmicb-13-757084-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/5119c5b40a64/fmicb-13-757084-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/6044a76949b0/fmicb-13-757084-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/70e4c4ece036/fmicb-13-757084-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/ca3b4d7a6912/fmicb-13-757084-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/960d/8882863/5cbccf424048/fmicb-13-757084-g005.jpg

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