Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892-5430.
Biological Sciences Graduate Program, University of Maryland, College Park, MD 20740.
Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2117930119. doi: 10.1073/pnas.2117930119. Epub 2022 Mar 3.
SignificanceWhile most small, regulatory RNAs are thought to be "noncoding," a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.
意义虽然大多数小的调节 RNA 被认为是“非编码”的，但也有一些被发现还编码一个小的蛋白质。在这里，我们描述了一个 164 个核苷酸的 RNA，它编码一个 28 个氨基酸的两亲性蛋白质，该蛋白质与需氧甘油-3-磷酸脱氢酶相互作用，增加脱氢酶的活性，但也与两个 mRNA 碱基配对以减少表达。编码和碱基配对序列重叠，两个调节功能相互竞争。
