Willigenburg Thomas, Zachiu Cornel, Lagendijk Jan J W, van der Voort van Zyp Jochem R N, de Boer Hans C J, Raaymakers Bas W
University Medical Centre Utrecht, Department of Radiation Oncology, 3508 GA Utrecht, The Netherlands.
Phys Imaging Radiat Oncol. 2022 Feb 17;21:62-65. doi: 10.1016/j.phro.2022.02.008. eCollection 2022 Jan.
To facilitate full intra-fraction adaptive MR-guided radiotherapy, accurate contour propagation is needed. We aimed to assess the clinical usability of intra-fraction propagated contours by a deformable image registration algorithm in ten prostate cancer patients. Two observers judged the contours on need for manual adaptation and feasibility of adapting contours within 3 min. CTV and bladder contours needed none or only minor editing in most cases (≥ 97%), whereas rectum contours needed more extensive editing in 12-23%. Nevertheless, adaptation times were < 3 min for ≥ 93% of the cases. This paves the way for exploring adaptive workflows using intra-fraction deformable contour propagation.
为促进全分次内自适应磁共振引导放疗，需要精确的轮廓传播。我们旨在通过可变形图像配准算法评估10例前列腺癌患者分次内传播轮廓的临床可用性。两名观察者判断轮廓是否需要手动调整以及在3分钟内调整轮廓的可行性。在大多数情况下（≥97%），临床靶区（CTV）和膀胱轮廓无需或仅需少量编辑，而直肠轮廓在12%-23%的情况下需要更广泛的编辑。尽管如此，≥93%的病例调整时间<3分钟。这为探索使用分次内可变形轮廓传播的自适应工作流程铺平了道路。
