Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
The First Affiliated Hospital, Medical Imaging Centre, Hengyang Medical School, University of South China, Hengyang, Hunan, China; Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China.
Ultrason Sonochem. 2022 Mar;84:105972. doi: 10.1016/j.ultsonch.2022.105972. Epub 2022 Mar 2.
Among various novel antimicrobial therapies, sonodynamic therapy (SDT) exhibits its advantages for the treatment of bacterial infections due to its high penetration depth and low side effects. In this study, a new nanosonosensitizer (HFH@ZIF-8) that loads sonosensitizer hematoporphyrin monomethyl ether (HMME) into zeolitic imidazolate framework-8 (ZIF-8), was constructed for killing multidrug-resistant (MDR) bacteria and treatment of in vivo infection diseases by SDT. In particular, the developed HFH@ZIF-8 exhibited enhanced water-solubility, good biocompatibility, and improved disease-targeting capability for delivering and releasing HMME and ablating the infected lesion. More importantly, the presence of oxygen-carrying hemoglobin for HFH@ZIF-8 can offer sufficient oxygen consumption by SDT, augmenting the efficacy of SDT by improving ROS generating efficiency against deep tissue multidrug-resistant bacterial infection. Therefore, this study paves a new avenue for treating infection disease, particularly for antibiotic resistant bacterial infection.
在各种新型抗菌治疗方法中，声动力学疗法（SDT）因其具有较高的穿透深度和较低的副作用，在治疗细菌感染方面显示出其优势。在本研究中，构建了一种新型纳米声敏剂（HFH@ZIF-8），将声敏剂血卟啉单甲醚（HMME）负载到沸石咪唑酯骨架-8（ZIF-8）中，通过 SDT 杀死多药耐药（MDR）细菌和治疗体内感染性疾病。特别是，所开发的 HFH@ZIF-8 表现出增强的水溶性、良好的生物相容性和改善的疾病靶向能力，可用于递送和释放 HMME 并消融感染病灶。更重要的是，HFH@ZIF-8 中携带氧的血红蛋白可为 SDT 提供足够的耗氧量，通过提高针对深部组织多药耐药细菌感染的 ROS 生成效率来增强 SDT 的疗效。因此，本研究为治疗感染性疾病，特别是对抗生素耐药性细菌感染开辟了新途径。
