Zhang Jianguo, Hu Jianhui, Huang Xing, Fu Shixiang, Ding Daoyin, Tao Zhimin
Department of Emergency Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Laboratory Medicine, Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine, Zhenjiang Hospital of Traditional Chinese Medicine, Zhenjiang, China.
Front Med (Lausanne). 2022 Feb 21;9:837411. doi: 10.3389/fmed.2022.837411. eCollection 2022.
Studies have discovered that wild-type SARS-CoV-2 infections are commonly linked to abnormalities in the hematological profiles of COVID-19 patients, one such abnormality being characterized by elevations in red blood cell distribution width (RDW). Whether this linkage reoccurs in delta variant SARS-CoV-2 infection remains unexamined. Here we compared baseline blood parameters in COVID-19 patients infected by wild type and its delta variant, respectively. Our results here point to that although the delta variant has shown increased virulence, transmissibility, and vaccine escape, it has a minimally negative impact on RDW values that were previously found prognostic for COVID-19 severity.
研究发现，野生型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染通常与2019冠状病毒病（COVID-19）患者血液学指标异常有关，其中一种异常表现为红细胞分布宽度（RDW）升高。这种关联在德尔塔变异株SARS-CoV-2感染中是否再次出现仍未得到研究。在此，我们比较了分别感染野生型及其德尔塔变异株的COVID-19患者的基线血液参数。我们的研究结果表明，尽管德尔塔变异株的毒力、传播力有所增加且出现了疫苗逃逸，但它对RDW值的负面影响极小，而RDW值此前被发现可预测COVID-19的严重程度。
