红细胞分布宽度与新冠病毒德尔塔变异株感染中COVID-19严重程度之间的关联
Association Between Red Blood Cell Distribution Width and COVID-19 Severity in Delta Variant SARS-CoV-2 Infection.
作者信息
Zhang Jianguo, Hu Jianhui, Huang Xing, Fu Shixiang, Ding Daoyin, Tao Zhimin
机构信息
Department of Emergency Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Laboratory Medicine, Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine, Zhenjiang Hospital of Traditional Chinese Medicine, Zhenjiang, China.
出版信息
Front Med (Lausanne). 2022 Feb 21;9:837411. doi: 10.3389/fmed.2022.837411. eCollection 2022.
Abstract
Studies have discovered that wild-type SARS-CoV-2 infections are commonly linked to abnormalities in the hematological profiles of COVID-19 patients, one such abnormality being characterized by elevations in red blood cell distribution width (RDW). Whether this linkage reoccurs in delta variant SARS-CoV-2 infection remains unexamined. Here we compared baseline blood parameters in COVID-19 patients infected by wild type and its delta variant, respectively. Our results here point to that although the delta variant has shown increased virulence, transmissibility, and vaccine escape, it has a minimally negative impact on RDW values that were previously found prognostic for COVID-19 severity.
摘要
研究发现，野生型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染通常与2019冠状病毒病（COVID-19）患者血液学指标异常有关，其中一种异常表现为红细胞分布宽度（RDW）升高。这种关联在德尔塔变异株SARS-CoV-2感染中是否再次出现仍未得到研究。在此，我们比较了分别感染野生型及其德尔塔变异株的COVID-19患者的基线血液参数。我们的研究结果表明，尽管德尔塔变异株的毒力、传播力有所增加且出现了疫苗逃逸，但它对RDW值的负面影响极小，而RDW值此前被发现可预测COVID-19的严重程度。
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2
Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC - China, July-August, 2021.
China CDC Wkly. 2021 Oct 8;3(41):863-868. doi: 10.46234/ccdcw2021.213.
3
Comparative Study of Acute Lung Injury in COVID-19 and Non-COVID-19 Patients.
Front Med (Lausanne). 2021 Aug 16;8:666629. doi: 10.3389/fmed.2021.666629. eCollection 2021.
4
Evaluating red blood cell distribution width from community blood tests as a predictor of hospitalization and mortality in adults with SARS-CoV-2: a cohort study.
Ann Med. 2021 Dec;53(1):1410-1418. doi: 10.1080/07853890.2021.1968484.
5
Role of red blood cell distribution width, as a prognostic indicator in COVID-19: A systematic review and meta-analysis.
Rev Med Virol. 2022 Mar;32(2):e2264. doi: 10.1002/rmv.2264. Epub 2021 Jun 6.
6
SARS-CoV-2 variants, spike mutations and immune escape.
Nat Rev Microbiol. 2021 Jul;19(7):409-424. doi: 10.1038/s41579-021-00573-0. Epub 2021 Jun 1.
7
Platelet-driven coagulopathy in COVID-19 patients: in comparison to seasonal influenza cases.
Exp Hematol Oncol. 2021 May 31;10(1):34. doi: 10.1186/s40164-021-00228-z.
8
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