ImFINE Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Física y del Deporte-INEF, Universidad Politécnica de Madrid, 28040 Madrid, Spain.
Clinical Laboratory Unit, Department of Sport and Health, Spanish Agency for Health Protection in Sport (Agencia Española de Protección de la Salud en el Deporte-AEPSAD), 28040 Madrid, Spain.
Int J Environ Res Public Health. 2022 Mar 5;19(5):3059. doi: 10.3390/ijerph19053059.
The purpose of this study was to show how continuous exercise affects the basal values of biochemical and hematological parameters in elite athletes. A total of 14,010 samples (male = 8452 and female = 5558 (March 2011-March 2020)) from 3588 elite athletes (male = 2258 and female = 1330, mean age 24.9 ± 6.9 vs. 24.1 ± 5.5 years, respectively) from 32 sport modalities, were studied over 9 years to check the variation of basal biochemical and hematological parameter values. There were differences seen in the basal values of creatine kinase (CK), urea, creatinine, aspartate transaminase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), potassium, total bilirubin, and eosinophil percentage compared to reference population data. However, other analytes showed narrow ranges of variation like glucose, total protein, albumin, sodium, hemoglobin, mean cell volume (MCV), and platelet count. Exercise produces changes in biochemical and hematological basal values of athletes compared to the general population, with the greatest variation in CK, but AST, ALT, LDH, potassium, and total bilirubin (TBil) show high values in serum, only with a wider distribution of values. The data here reflects the effect of exercise on biochemical and hematological parameter baseline ranges in elite athletes. As clinical laboratories use reference intervals to validate clinical reports, these "pseudo" reference intervals should be used when validating laboratory reports.
本研究旨在展示连续运动如何影响精英运动员生化和血液学参数的基础值。在 9 年的时间里，对来自 32 种运动项目的 3588 名精英运动员（男性 2258 名，女性 1330 名，平均年龄分别为 24.9±6.9 岁和 24.1±5.5 岁）的 14010 个样本（男性 8452 个，女性 5558 个）进行了研究，以检查基础生化和血液学参数值的变化。与参考人群数据相比，肌酸激酶（CK）、尿素、肌酐、天门冬氨酸转氨酶（AST）、丙氨酸氨基转移酶（ALT）、乳酸脱氢酶（LDH）、钾、总胆红素和嗜酸性粒细胞百分比的基础值存在差异。然而，其他分析物的变化范围较窄，如葡萄糖、总蛋白、白蛋白、钠、血红蛋白、平均细胞体积（MCV）和血小板计数。与一般人群相比，运动对运动员的生化和血液学基础值产生了变化，其中 CK 的变化最大，但 AST、ALT、LDH、钾和总胆红素（TBil）在血清中的值较高，只是值的分布范围较宽。这里的数据反映了运动对精英运动员生化和血液学参数基础值范围的影响。由于临床实验室使用参考区间来验证临床报告，因此在验证实验室报告时应使用这些“伪”参考区间。
