Dipartimento di Matematica e Fisica, Universit'a degli Studi della Campania "Luigi Vanvitelli", Caserta 81100, Italy.
Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Comput Biol Chem. 2022 Jun;98:107645. doi: 10.1016/j.compbiolchem.2022.107645. Epub 2022 Feb 19.
In this paper, a compartmental mathematical model has been utilized to gain a better insight about the future dynamics of COVID-19. The total human population is divided into eight various compartments including susceptible, exposed, pre-asymptomatic, asymptomatic, symptomatic, quarantined, hospitalized and recovered or removed individuals. The problem was modeled in terms of highly nonlinear coupled system of classical order ordinary differential equations (ODEs) which was further generalized with the Atangana-Balaeanu (ABC) fractional derivative in Caputo sense with nonlocal kernel. Furthermore, some theoretical analyses have been done such as boundedness, positivity, existence and uniqueness of the considered. Disease-free and endemic equilibrium points were also assessed. The basic reproduction was calculated through next generation technique. Due to high risk of infection, in the present study, we have considered the reported cases from three continents namely Americas, Europe, and south-east Asia. The reported cases were considered between 1st May 2021 and 31st July 2021 and on the basis of this data, the spread of infection is predicted for the next 200 days. The graphical solution of the considered nonlinear fractional model was obtained via numerical scheme by implementing the MATLAB software. Based on the fitted values of parameters, the basic reproduction number ℜ for the case of America, Asia and Europe were calculated as ℜ≈2.92819, ℜ≈2.87970 and ℜ≈2.23507 respectively. It is also observed that the spread of infection in America is comparatively high followed by Asia and Europe. Moreover, the effect of fractional parameter is shown on the dynamics of spread of infection among different classes. Additionally, the effect of quarantined and treatment of infected individuals is also shown graphically. From the present analysis it is observed that awareness of being quarantine and proper treatment can reduce the infection rate dramatically and a minimal variation in quarantine and treatment rates of infected individuals can lead us to decrease the rate of infection.
本文利用房室数学模型深入了解 COVID-19 的未来动态。总人口分为八个不同的群体,包括易感人群、暴露人群、潜伏期、无症状、有症状、隔离、住院和康复或移除人群。该问题采用高度非线性的经典常微分方程组(ODE)建模,并进一步推广为具有非局部核的 Atangana-Balaeanu(ABC)分数阶导数。此外,还进行了一些理论分析,如边界性、正定性、存在性和唯一性。还评估了无病和地方病平衡点。通过下一代技术计算基本繁殖数。由于感染风险高,在本研究中,我们考虑了来自三个大陆(美洲、欧洲和东南亚)的报告病例。报告病例时间为 2021 年 5 月 1 日至 7 月 31 日,并根据这些数据预测未来 200 天的感染传播情况。通过实施 MATLAB 软件的数值方案获得所考虑的非线性分数模型的图形解。根据拟合参数值,计算出美国、亚洲和欧洲的基本繁殖数 ℜ分别为 ℜ≈2.92819、ℜ≈2.87970 和 ℜ≈2.23507。还观察到,美国的感染传播速度相对较高,其次是亚洲和欧洲。此外,分数阶参数对不同群体感染传播动力学的影响也有所体现。此外,还通过图形方式展示了隔离和治疗感染个体的效果。从目前的分析来看,意识到被隔离和进行适当的治疗可以显著降低感染率,而隔离和治疗感染个体的比率的微小变化可以降低感染率。