生酮饮食：对肌少症性肥胖有效吗？
The Ketogenic Diet: Is It an Answer for Sarcopenic Obesity?
机构信息
Department of Laboratory, Bahrain Specialist Hospital, Juffair P.O. Box 10588, Bahrain.
Department of Biology, College of Science, Sakhir Campus, University of Bahrain, Zallaq P.O. Box 32038, Bahrain.
出版信息
Nutrients. 2022 Jan 30;14(3):620. doi: 10.3390/nu14030620.
Abstract
This review aims to define the effectiveness of the ketogenic diet (KD) for the management of sarcopenic obesity. As the combination of sarcopenia and obesity appears to have multiple negative metabolic effects, this narrative review discusses the effects of the ketogenic diet as a possible synergic intervention to decrease visceral adipose tissue (VAT) and fatty infiltration of the liver as well as modulate and improve the gut microbiota, inflammation and body composition. The results of this review support the evidence that the KD improves metabolic health and expands adipose tissue γδ T cells that are important for glycaemia control during obesity. The KD is also a therapeutic option for individuals with sarcopenic obesity due to its positive effect on VAT, adipose tissue, cytokines such as blood biochemistry, gut microbiota, and body composition. However, the long-term effect of a KD on these outcomes requires further investigations before general recommendations can be made.
摘要
这篇综述旨在定义生酮饮食（KD）在治疗肌少症性肥胖中的有效性。由于肌少症和肥胖的结合似乎具有多种负面代谢效应，因此本综述讨论了生酮饮食作为一种可能的协同干预措施，以减少内脏脂肪组织（VAT）和肝脏脂肪浸润，以及调节和改善肠道微生物群、炎症和身体成分的效果。这篇综述的结果支持了这样的证据，即 KD 可以改善代谢健康，并增加脂肪组织 γδ T 细胞，这对于肥胖期间的血糖控制很重要。由于 KD 对 VAT、脂肪组织、细胞因子（如血液生化）、肠道微生物群和身体成分有积极影响，因此 KD 也是肌少症性肥胖患者的一种治疗选择。然而，在提出一般性建议之前，还需要进一步研究 KD 对这些结果的长期影响。
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