Lum Pei Teng, Sekar Mahendran, Gan Siew Hua, Jeyabalan Srikanth, Bonam Srinivasa Reddy, Rani Nur Najihah Izzati Mat, Ku-Mahdzir Ku-Marina, Seow Lay Jing, Wu Yuan Seng, Subramaniyan Vetriselvan, Fuloria Neeraj Kumar, Fuloria Shivkanya
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh - 30450, Perak, Malaysia.
School of Pharmacy, Monash University Malaysia, Bandar Sunway - 47500, Selangor Darul Ehsan, Malaysia.
Saudi J Biol Sci. 2022 Mar;29(3):1530-1542. doi: 10.1016/j.sjbs.2021.11.016. Epub 2021 Nov 16.
There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and modulates cell signalling pathways. The purpose of this review provide a brief overview of the reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney disorders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent therapeutic potential in managing kidney disorders. Thus, in addition to this review, molecular docking is performed against nuclear factor kappa B (NF-κB) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective molecule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-κB and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clinical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disorders in humans.
由于天然产物相对于合成化合物具有较低的毒性，因此在将其用作有效的药物治疗剂方面的研究发展有了转变。在天然产物中，芒果苷是一种天然的C-葡萄糖基黄酮多酚，具有显著的药理活性。新出现的证据表明，在实验动物模型中，芒果苷对各种肾脏疾病具有治疗作用，包括肾损伤、糖尿病肾病、肾纤维化、高尿酸血症肾病和狼疮性肾炎。芒果苷诱导抗氧化反应，从而发挥重要作用，如预防肾脏炎症、抑制肾细胞凋亡、激活自噬、引起免疫调节、调节肾脏尿酸转运蛋白和调节细胞信号通路。本综述的目的是简要概述芒果苷的肾脏保护作用及其预防肾脏疾病的潜在机制。由于芒果苷在治疗肾脏疾病方面具有出色的治疗潜力，因此了解其药理作用非常重要。因此，除了本综述之外，还针对核因子κB（NF-κB）和可溶性环氧化物水解酶（sEH）进行了分子对接，以研究芒果苷的作用机制。人们认为芒果苷是一种安全的肾脏保护分子。观察到的积极作用归因于对由NF-κB和sEH上调以及氧化应激激活引起的炎症的抑制。进一步有必要对芒果苷在临床试验中的疗效和安全性进行研究，以确认其作为人类肾脏疾病治疗剂的药用潜力。
