Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, Shandong, China.
Department of Dermatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, 266035, Shandong, China.
Int J Biol Sci. 2022 Jan 24;18(4):1451-1475. doi: 10.7150/ijbs.68170. eCollection 2022.
Flavonoids are a group of polyphenolic compounds which are ubiquitously found in plants and are consumed as part of the human diet in substantial amounts. The verification of flavonoids' cancer chemopreventive benefits has led to a significant interest in this field. Gut microbiota includes a diverse community of microorganisms and has a close relationship with cancer development. Increasing evidence has indicated that flavonoids exert anticarcinogenic effects by reshaping gut microbiota. Gut microbiota can convert flavonoids into bioactive metabolites that possess anticancer activity. Here, we present a brief introduction to gut microbiota and provide an overview of the interplay between gut microbiota and cancer pathogenesis. We also highlight the crucial roles of flavonoids in preventing cancer based on their regulation of gut microbiota. This review would encourage research on the flavonoid-intestinal microbiota interactions and clinical trials to validate the chemotherapeutic potentials of targeting gut microbiota by dietary bioactive compounds.
类黄酮是一类广泛存在于植物中的多酚化合物，作为人类饮食的一部分，其摄入量相当可观。类黄酮的抗癌化学预防作用已得到证实，这使得人们对该领域产生了浓厚的兴趣。肠道微生物群包含了多种多样的微生物群落，与癌症的发生发展有着密切的关系。越来越多的证据表明，类黄酮通过重塑肠道微生物群来发挥抗癌作用。肠道微生物群可以将类黄酮转化为具有抗癌活性的生物活性代谢物。在这里，我们简要介绍了肠道微生物群，并概述了肠道微生物群与癌症发病机制之间的相互作用。我们还强调了类黄酮通过调节肠道微生物群来预防癌症的关键作用。这篇综述将鼓励人们研究类黄酮-肠道微生物群的相互作用，并开展临床试验，以验证通过饮食生物活性化合物靶向肠道微生物群的化疗潜力。
