Britton Julia J L, El-Defrawy Sherif, Wong Bryan M, Chandrakumar Manokaraananthan, Omali Negar B, Pham Song, Hatch Wendy
Faculty of Medicine, National University of Ireland-Galway, Galway, Ireland.
Department of Ophthalmology and Vision Science, Kensington Eye Institute, Toronto, Ontario, Canada.
Clin Ophthalmol. 2022 Mar 5;16:669-676. doi: 10.2147/OPTH.S339385. eCollection 2022.
To compare the trifocal TFNT00 and extended depth-of-focus (EDF) ZXR00 intraocular lenses (IOLs) with respect to overall satisfaction with near and distance vision, visual acuity, dysphotopsia symptoms, spectacle dependence, and mesopic best corrected contrast sensitivity (MBCCS).
This non-randomized, retrospective, single-centre, comparative study took place at the Kensington Eye Institute in Toronto, Canada. Subjects implanted with either the TFNT00 IOL (n = 11) or ZXR00 IOL (n = 13) were assessed up to 4 years post operatively. Overall satisfaction with distance and near vision, corrected distance visual acuity, uncorrected visual acuity at distance, intermediate (60 cm) and near (40 cm) (UNVA), dysphotopsia symptoms, spectacle dependence and monocular MBCCS were evaluated.
Forty-eight eyes of 24 subjects (mean age 68 years, 54% female) were assessed. There was no difference in overall satisfaction; both groups had a median score of 10/10 for overall distance vision, and 7/10 and 8/10 for near vision for EDF and trifocal, respectively. MBCCS at the higher spatial frequencies was significantly better with the ZXR00 IOL. Potentially clinically relevant but not statistically significant differences were found; the trifocal group (vs the EDF group) had better binocular UNVA (20/24 vs 20/32) and less spectacle dependence at least some of the time (54% vs 85%).
The ZXR00 may be preferred for those who want optimal contrast sensitivity in dim lighting. Consistent with previous studies, the TFNT00 trifocal IOL may be a better choice for those who want to optimize UNVA. More studies in North America are required to further investigate spectacle dependence.
比较三焦点TFNT00人工晶状体（IOL）和扩展焦深（EDF）ZXR00人工晶状体在近视力和远视力的总体满意度、视力、眩光症状、对眼镜的依赖程度以及中视最佳矫正对比敏感度（MBCCS）方面的差异。
这项非随机、回顾性、单中心的比较研究在加拿大多伦多的肯辛顿眼科研究所进行。对植入TFNT00 IOL（n = 11）或ZXR00 IOL（n = 13）的受试者进行了长达术后4年的评估。评估了对远视力和近视力的总体满意度、矫正远视力、远距离、中间距离（60厘米）和近距离（40厘米）的未矫正视力（UNVA）、眩光症状、对眼镜的依赖程度以及单眼MBCCS。
对24名受试者（平均年龄68岁，54%为女性）的48只眼睛进行了评估。总体满意度无差异；两组远视力的中位数评分均为10/10，EDF组和三焦点组近视力的中位数评分分别为7/10和8/10。ZXR00 IOL在较高空间频率下的MBCCS明显更好。发现了潜在的临床相关但无统计学意义的差异；三焦点组（与EDF组相比）至少在某些时候具有更好的双眼UNVA（20/24 vs 20/32）和更低的对眼镜的依赖程度（54% vs 85%）。
对于那些希望在暗光下获得最佳对比敏感度的人来说，ZXR00可能是更好的选择。与先前的研究一致，对于那些希望优化UNVA的人来说，TFNT00三焦点IOL可能是更好的选择。需要在北美进行更多研究以进一步调查对眼镜的依赖程度。
