Institute of Neurology, National Clinical Research Center for Aging and Medicine, National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai, China.
Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
Alzheimers Dement. 2023 Jan;19(1):107-122. doi: 10.1002/alz.12628. Epub 2022 Mar 15.
Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.
We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults.
Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week).
This cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.
尽管已有大量证据表明，身体活动可能会延缓痴呆的发生，但所需活动的持续时间和量仍不清楚。
我们协调了来自 8 个国家的 10 个队列的 11988 名参与者的纵向数据，以研究老年人晚年身体活动与痴呆发病之间的剂量反应关系。
以不进行任何身体活动为参照，痴呆风险随身体活动时间的增加而降低，持续时间为 0.1 至 3.0 小时/周（危险比 [HR] 0.88，95%置信区间 [CI] 0.67 至 1.15；3.1 至 6.0 小时/周的 HR 0.68，95%CI 0.52 至 0.89），但随着时间的延长而趋于平稳。对于身体活动量，也观察到类似的剂量反应曲线模式，拐点为 9.1 至 18.0 代谢当量（MET）-小时/周（0.1 至 9.0 MET-小时/周的 HR 0.92，95%CI 0.70 至 1.22；9.1 至 18.0 MET-小时/周的 HR 0.70，95%CI 0.53 至 0.93）。
这项跨国分析表明，每周进行 3.1 至 6.0 小时的身体活动和消耗 9.1 至 18.0/MET 小时的能量可能会降低痴呆风险。
