Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Parasitol Res. 2013 Nov;112(11):3697-701. doi: 10.1007/s00436-013-3555-4. Epub 2013 Aug 7.
The effectiveness of antimalarial drugs is declining at an ever accelerating rate, with consequent increase in malaria-related morbidity and mortality. The newest antiplasmodial drug from plants is needed to overcome this problem. The aim of this study was to assess antimalarial activity of the ethanolic extracts of 10 different medicinal plants from eight families against Plasmodium falciparum chloroquine-sensitive 3D7 strain. The selection of the hereby studied plants was based on the existing information on their local ethnobotanic history. Plants were dried, powdered, and macerated in a hydroalcoholic solution. Resulting extracts have been assessed for in vitro and in vivo antimalarial and brine shrimp toxicity activities. Of 10 plant species tested, four plants: Althea officinalis L. (Malvaceae), Myrtus communis Linn (Myrtaceae), Plantago major (Plantaginaceae), and Glycyrrhiza glabra L. (Papilionaceae) displayed promising antimalarial activity in vitro (50% inhibitory concentration values of 62.77, 42.18, 40.00, and 13.56 μg/mL, respectively) with no toxicity against brine shrimp larvae. The crude extracts of three active plants, G. glabra, M. communis, and A. officinalis, also significantly reduced parasitemia in vivo in female Swiss albino mice at a dose of 400 mg/kg compared to no treatment. Antiplasmodial activities of extracts of A. officinalis and M. communis are reported for the first time.
抗疟药物的有效性正在以越来越快的速度下降，随之而来的是疟疾发病率和死亡率的上升。需要从植物中提取最新的抗疟药物来解决这个问题。本研究的目的是评估来自 8 个科的 10 种不同药用植物的乙醇提取物对青蒿素敏感的 3D7 疟原虫株的抗疟活性。选择研究的植物是基于它们在当地民族植物学历史上的现有信息。植物被干燥、粉碎并在水醇溶液中浸渍。所得提取物已被评估用于体外和体内抗疟和盐水虾毒性活性。在测试的 10 种植物中，有 4 种植物（锦葵科的芙蓉、桃金娘科的桃金娘、车前草科的车前草和豆科的甘草）表现出有希望的体外抗疟活性（50%抑制浓度值分别为 62.77、42.18、40.00 和 13.56 μg/mL），对盐水虾幼虫没有毒性。三种活性植物（甘草、桃金娘和芙蓉）的粗提取物在 400mg/kg 剂量下也显著降低了雌性瑞士白化小鼠体内的寄生虫血症，与未治疗组相比。芙蓉和桃金娘提取物的抗疟活性是首次报道。
