Masiuk Sergii, Chepurny Mykola, Buderatska Valentyna, Ivanova Olga, Boiko Zulfira, Zhadan Natalia, Hatch Maureen, Cahoon Elizabeth K, Zamotayeva Galyna, Shpak Victor, Tronko Mykola, Drozdovitch Vladimir
State Institution "National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine", Kyiv, 04050, Ukraine.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA.
J Radiat Res. 2022 May 18;63(3):364-377. doi: 10.1093/jrr/rrac007.
This study revised the thyroid doses for 2582 Ukrainian in utero cohort members exposed to Chornobyl fallout (the Ukrainian in utero cohort) based on revision of: (i) 131I thyroid activity measured in the Ukrainian population, (ii) thyroid dosimetry system for entire Ukraine, and (iii) 131I ground deposition densities in Ukraine. Other major improvements included: (i) assessment of uncertainties in the thyroid doses considering shared and unshared error, and (ii) accounting for intake of short-lived radioisotopes of tellurium and iodine (132Te+132I and 133I). Intake of 131I was the major pathway for thyroid exposure, its median contribution to the thyroid dose was 97.4%. The mean prenatal and postnatal thyroid dose from 131I was 87 mGy (median = 17 mGy), higher than previous deterministic dose of 72 mGy (median = 12 mGy). For 39 individuals (1.5%) the dose exceeded 1.0 Gy, while the highest dose among the cohort members was 2.7 Gy. The geometric standard deviation (GSD) of 1000 individual stochastic doses varied from 1.9 to 5.2 with a mean of 3.1 and a median of 3.2. The lowest uncertainty (mean GSD = 2.3, median GSD = 2.2) was found for the subjects whose mothers were measured for 131I thyroid activity, while for individuals, whose mothers were not measured, the mean and median GSDs were 3.4. Uncertainties in thyroid doses were driven by shared errors associated with the parameters of the ecological model.
本研究基于以下方面的修订，对2582名暴露于切尔诺贝利放射性尘埃的乌克兰宫内队列成员（乌克兰宫内队列）的甲状腺剂量进行了重新估算：（i）对乌克兰人群中测量的¹³¹I甲状腺活度；（ii）整个乌克兰的甲状腺剂量测定系统；以及（iii）乌克兰的¹³¹I地面沉积密度。其他主要改进包括：（i）考虑共同误差和非共同误差评估甲状腺剂量的不确定性；以及（ii）考虑碲和碘的短寿命放射性同位素（¹³²Te + ¹³²I和¹³³I）的摄入量。¹³¹I的摄入是甲状腺暴露的主要途径，其对甲状腺剂量的中位数贡献为97.4%。¹³¹I所致的产前和产后甲状腺平均剂量为87 mGy（中位数 = 17 mGy），高于先前确定的72 mGy（中位数 = 12 mGy）。有39人（1.5%）的剂量超过1.0 Gy，而队列成员中的最高剂量为2.7 Gy。1000个个体随机剂量的几何标准差（GSD）在1.9至5.2之间变化，平均值为3.1，中位数为3.2。对于其母亲测量了¹³¹I甲状腺活度水平的受试者，不确定性最低（平均GSD = 2.3，中位数GSD = 2.2），而对于其母亲未进行测量的个体，平均和中位数GSD为3.4。甲状腺剂量的不确定性是由与生态模型参数相关的共同误差驱动的。
