University of Melbourne, Parkville, VIC 3053, Australia.
Consultant Oral and Maxillofacial Surgeon, Epworth Freemasons Hospital, 166 Clarendon Street, East Melbourne, VIC 3002, Australia.
Br J Oral Maxillofac Surg. 2022 May;60(4):387-396. doi: 10.1016/j.bjoms.2021.06.017. Epub 2021 Jul 29.
The aim of this review was to assess the level of evidence for genetic, biological, and functional predictive and predisposing factors for end-stage temporomandibular joint arthritis within the published literature. A comprehensive review based upon PRISMA guidelines was performed from all literature relevant to the topic. Case series and animal studies were included given the rare nature of the disease and goal of finding root-cause predictive factors. Clinical and radiographic measures were used specifically to identify factors which may have contributed to disease onset and progression. A total of 249 abstracts were identified based on search terms of major databases. After application of exclusion and inclusion criteria, 63 full-text articles were included in the analysis of this paper. There were few factors that could be reliably used to predict end-stage temporomandibular joint disease. Limited evidence is available to adequately predict end-stage temporomandibular joint osteoarthritis. No descriptive process exists that explains how and why this process can occur in younger adults. A better understanding of the aetiology and pathogenesis of TMJ-OA may lead to prevention and more effective management strategies that may reduce the need for drastic surgical intervention, particularly in young adults.
本综述的目的是评估已发表文献中有关颞下颌关节关节炎终末期的遗传、生物学和功能预测和易患因素的证据水平。根据 PRISMA 指南，对与该主题相关的所有文献进行了全面综述。鉴于该疾病的罕见性和寻找根本原因预测因素的目标，纳入了病例系列和动物研究。临床和影像学测量专门用于确定可能导致疾病发作和进展的因素。根据主要数据库的搜索词，共确定了 249 个摘要。经过排除和纳入标准的应用，共有 63 篇全文文章纳入本论文的分析。能够可靠地用于预测颞下颌关节终末期疾病的因素很少。现有证据不足以充分预测颞下颌关节骨关节炎的终末期。目前还没有描述性的过程来解释这个过程为什么以及如何会在年轻人中发生。更好地了解 TMJ-OA 的病因和发病机制可能会导致预防和更有效的管理策略，从而减少对剧烈手术干预的需求，特别是在年轻人中。
