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LINC00520：癌症潜在的诊断和预后生物标志物。

LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer.

机构信息

School of Medicine, Zhejiang University City College, Hangzhou, China.

Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.

出版信息

Front Immunol. 2022 Mar 2;13:845418. doi: 10.3389/fimmu.2022.845418. eCollection 2022.

DOI:10.3389/fimmu.2022.845418
PMID:35309319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8924041/
Abstract

Long non-coding RNA (lncRNA) is important in the study of cancer mechanisms. LINC00520 is located on human chromosome 14q22.3 and is a highly conserved long non-coding RNA. LINC00520 is widely expressed in various tissues. The expression of LINC00520 is regulated by transcription factors such as Sp1, TFAP4, and STAT3. The high expression of LINC00520 is significantly related to the risk of 11 cancers. LINC00520 can competitively bind 10 miRNAs to promote tumor cell proliferation, invasion, and migration. In addition, LINC00520 is involved in the regulation of P13K/AKT and JAK/STAT signaling pathways. The expression of LINC00520 is significantly related to the clinicopathological characteristics and prognosis of tumor patients and is also related to the sensitivity of HNSCC to radiotherapy. Here, this article summarizes the abnormal expression pattern of LINC00520 in cancer and its potential molecular regulation mechanism and points out that LINC00520 can be used as a potential biomarker for cancer diagnosis, prognosis, and treatment.

摘要

长链非编码 RNA（lncRNA）在癌症机制研究中具有重要作用。LINC00520 位于人类染色体 14q22.3 上，是一种高度保守的长链非编码 RNA。LINC00520 在各种组织中广泛表达。LINC00520 的表达受转录因子如 Sp1、TFAP4 和 STAT3 等调控。LINC00520 的高表达与 11 种癌症的风险显著相关。LINC00520 可以竞争性地结合 10 个 miRNA 来促进肿瘤细胞的增殖、侵袭和迁移。此外，LINC00520 参与调节 PI3K/AKT 和 JAK/STAT 信号通路。LINC00520 的表达与肿瘤患者的临床病理特征和预后显著相关，也与 HNSCC 对放疗的敏感性相关。本文总结了 LINC00520 在癌症中的异常表达模式及其潜在的分子调控机制，并指出 LINC00520 可以作为癌症诊断、预后和治疗的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/82fb301606ec/fimmu-13-845418-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/e870e1ab9bb2/fimmu-13-845418-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/e6ea7dd9a32e/fimmu-13-845418-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/34ae2f973508/fimmu-13-845418-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/82fb301606ec/fimmu-13-845418-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/e870e1ab9bb2/fimmu-13-845418-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/e6ea7dd9a32e/fimmu-13-845418-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/34ae2f973508/fimmu-13-845418-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba21/8924041/82fb301606ec/fimmu-13-845418-g004.jpg

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