印度南部喀拉拉邦一家三级医院献血者登革热血清阳性率。
Dengue seropositivity among blood donors in a tertiary hospital in Kerala, Southern India.
机构信息
Department of Microbiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Department of Transfusion Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
出版信息
Ann Afr Med. 2022 Jan-Mar;21(1):39-42. doi: 10.4103/aam.aam_72_20.
AIM
The aim of this study was to screen blood donors in a tertiary hospital in Kerala for dengue during the period of peak dengue transmission.
MATERIALS AND METHODS
One hundred and seventy-eight continuous serum samples obtained from asymptomatic blood donors during the monsoon season were subjected to ELISA for Dengue NS1 antigen and dengue immunoglobulin M (IgM) antibodies.
RESULTS
Dengue IgM antibodies were positive in 20 (11.23%) donors and NS1 antigen was positive in 1 (0.56%) donor. The presence of these markers in asymptomatic blood donors showed that they may have had active or subclinical dengue infection at the time of donation or in the recent past. The presence of NS1 in particular raises the possibility that the donor may have been viremic at the time of donation.
CONCLUSION
The findings of this study suggest the risk of transfusion transmission of dengue during the monsoon in Kerala and strengthen the case for dengue screening among blood donors during this period of high incidence.
目的
本研究旨在在登革热传播高峰期对喀拉拉邦一家三级医院的献血者进行登革热筛查。
材料与方法
在季风季节，从 178 名无症状献血者连续采集 178 份血清样本，采用 ELISA 法检测登革热 NS1 抗原和登革热免疫球蛋白 M（IgM）抗体。
结果
20 名（11.23%）献血者的登革热 IgM 抗体呈阳性，1 名（0.56%）献血者的 NS1 抗原呈阳性。无症状献血者中这些标志物的存在表明，他们在献血时或近期可能患有活动性或亚临床登革热感染。特别是 NS1 的存在提示献血者在献血时可能具有病毒血症。
结论
本研究结果表明，喀拉拉邦季风期间存在经输血传播登革热的风险，并且在高发期间对献血者进行登革热筛查的理由更加充分。
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