Wen Chan, Sun Ling, Zhao Meng-Chuan, Duan Su-Xia, Wang Le, Cui Xiao-Wei
Department of Medical, Children's Hospital of Hebei Province, Shijiazhuang, 050031, People's Republic of China.
Department of Laboratory Medicine, Children's Hospital of Hebei Province, Shijiazhuang, 050031, People's Republic of China.
Infect Drug Resist. 2022 Mar 16;15:1093-1101. doi: 10.2147/IDR.S357193. eCollection 2022.
This study aims to analyze the clinical characteristics of hospitalized children infected with HCoV-NL63, OC43, 229E, HKU1 and provide the basis for disease diagnosis and treatment.
A retrospective analysis was conducted on clinical manifestations, imaging data, and treatment measures of hospitalized children with positive HCoV-NL63, OC43, 229E, HKU1 from 2015 to 2020.
A total of 1062 children aged 33 days to 12 years were analyzed, including 879 (82.77%) between 33 days to three years. Lower respiratory tract infections were the most common in 698 children positive for HCoVs (65.72%). The incidences of runny nose, cough, pharyngeal hyperemia, and fine crackles in the mild case group (n = 894, 84.18%) were significantly higher than in the severe case group, and the differences were statistically significant ( < 0.01). The incidences of gasp, stridor, and convulsions, the proportion of underlying diseases, such as congenital heart disease, laryngomalacia, and general developmental disorders, anemia, and abnormal liver function, and mixed infections in the severe group (n = 168, 15.82%) were significantly higher than in the mild group, and the differences were statistically significant ( < 0.01 or < 0.05). Imaging manifestations differed. Pleural effusion and atelectasis occurred in the severe cases. After treatment, patients fully recovered or improved and were discharged from the hospital. There were no deaths.
HCoV-NL63, OC43, 229E, HKU1 infection is most common in children under three years old, and the infection site is mainly the lower respiratory tract. The main clinical manifestations include fever, cough, and runny nose. Inspiratory three concave signs, respiratory failure, and heart failure occurred in the severe cases, with pleural effusion and atelectasis possibly occurring at the same time. Severe cases should be identified early so that they may be given comprehensive treatment in time to improve the prognosis.
本研究旨在分析感染人冠状病毒NL63、OC43、229E、HKU1的住院儿童的临床特征，为疾病的诊断和治疗提供依据。
对2015年至2020年期间人冠状病毒NL63、OC43、229E、HKU1检测呈阳性的住院儿童的临床表现、影像资料及治疗措施进行回顾性分析。
共分析了1062例年龄在33天至12岁的儿童，其中879例（82.77%）年龄在33天至3岁之间。698例人冠状病毒检测呈阳性的儿童中，下呼吸道感染最为常见（65.72%）。轻症组（n = 894，84.18%）流涕、咳嗽、咽部充血及细湿啰音的发生率显著高于重症组，差异有统计学意义（<0.01）。重症组（n = 168，15.82%）气喘、喘鸣及惊厥的发生率、先天性心脏病、喉软化症、一般发育障碍、贫血及肝功能异常等基础疾病的比例以及混合感染的发生率均显著高于轻症组，差异有统计学意义（<0.01或<0.05）。影像表现有所不同。重症病例出现胸腔积液和肺不张。经治疗后，患者均完全康复或好转出院。无死亡病例。
人冠状病毒NL63、OC43、229E、HKU1感染在3岁以下儿童中最为常见，感染部位主要为下呼吸道。主要临床表现为发热、咳嗽和流涕。重症病例出现吸气性三凹征、呼吸衰竭和心力衰竭，可能同时出现胸腔积液和肺不张。应尽早识别重症病例，以便及时给予综合治疗，改善预后。
