Zhang Cuiping, Chen Yan, Fu Xiaobing
Stem Cell and Tissue Regeneration Laboratory, The First Affiliated Hospital, General Hospital of PLA, Beijing, PR China.
Department of Pharmacy, General Hospital of Beijing Military Region, Beijing, PR China.
Cytotherapy. 2015 May;17(5):526-35. doi: 10.1016/j.jcyt.2014.10.016. Epub 2014 Dec 18.
Stem cells are the seeds of tissue repair and regeneration and a promising source for novel therapies. The skin of patients with an extensive deep burn injury is repaired by a hypertrophic scar without regeneration of sweat glands and therefore loses the function of perspiration. Stem cell therapy provides the possibility of sweat gland regeneration. In particular, recent studies have reported the reprogramming of mesenchymal stromal cells into sweat gland-like (SGL) cells. We present an overview of recent researches into sweat gland regeneration with stem cells. Difficulties of sweat gland regeneration after deep burns have been elaborated. The advantage and disadvantage of several stem cell types in sweat gland regeneration have been discussed. Additionally, the possible mechanisms for reprogramming stem cells to SGL cells are summarized. A brief discussion on clinical application of stem cell-derived SGL cells is also presented. This review may possibly provide some implications for sweat gland regeneration.
干细胞是组织修复和再生的种子，也是新型疗法的一个有前景的来源。大面积深度烧伤患者的皮肤通过增生性瘢痕修复，汗腺无法再生，因此失去了排汗功能。干细胞疗法为汗腺再生提供了可能性。特别是，最近的研究报道了间充质基质细胞重编程为汗腺样（SGL）细胞。我们概述了最近关于干细胞汗腺再生的研究。阐述了深度烧伤后汗腺再生的困难。讨论了几种干细胞类型在汗腺再生中的优缺点。此外，总结了干细胞重编程为SGL细胞的可能机制。还简要讨论了干细胞来源的SGL细胞的临床应用。这篇综述可能会为汗腺再生提供一些启示。
