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两例 COVID-19 住院患者中曲霉菌内源性眼内炎的独特表现。

Unique presentations of aspergillosis endogenous endophthalmitis in two hospitalized patients with severe COVID-19.

机构信息

Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Giza; Watany Eye Hospital, Cairo, Egypt.

Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, India.

出版信息

Indian J Ophthalmol. 2022 Apr;70(4):1421-1424. doi: 10.4103/ijo.IJO_2718_21.

Abstract

We present two ICU-hospitalized patients with coronavirus disease-19 (COVID-19) presenting with endogenous endophthalmitis in one eye and variable manifestations of chorioretinitis in the fellow eye. Two diabetic patients (57 and 62 years old) showed anterior uveitis and yellowish-white subretinal infiltrations. The fellow eye of one patient showed patches of choroiditis, while the other showed full retinal thickness infiltrations. A workup yielded high serum titers of galactomannan, diagnostic of aspergillosis. The widespread use of high doses of corticosteroids in the management of COVID-19 may predispose to various secondary fungal opportunistic infections and may manifest in different forms of chorioretinal infiltration.

摘要

我们报告了两例 2 型糖尿病合并 COVID-19 的 ICU 住院患者,其中 1 例单侧眼表现为内源性眼内炎,对侧眼表现为脉络膜视网膜炎的多种不同表现。2 例患者均表现为前葡萄膜炎和黄白色的视网膜下浸润。其中 1 例对侧眼表现为脉络膜炎斑片,另 1 例则表现为全视网膜厚度浸润。实验室检查血清半乳甘露聚糖抗体滴度升高,诊断为曲霉菌病。COVID-19 患者大剂量糖皮质激素的广泛应用可能导致各种继发性真菌感染,并以不同形式的脉络膜视网膜浸润为表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bcb7/9240524/dddc3a94eb58/IJO-70-1421-g001.jpg

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