Helwig Nathaniel J, Schwager Laura E, Berry Alexander C, Zucker Anna C, Venenga Jacob S, Sterbenz Samantha C, Jenkins Nathaniel D M
University of Iowa, Department of Health and Human Physiology, Iowa City, IA, USA.
University of Iowa, Abboud Cardiovascular Research Center, Iowa City, IA, USA.
J Int Soc Sports Nutr. 2024 Dec;21(1):2379424. doi: 10.1080/15502783.2024.2379424. Epub 2024 Jul 16.
We conducted a randomized, double-blind, placebo-controlled crossover trial in young adults to examine the dose-dependent (600 mg versus 1200 mg), acute effects of consumption of an tea extract (GLE) on mood, cognitive and motor-cognitive performance, as well as its acute cardiovascular effects.
Twenty-five adults (mean ± SD, age = 28 ± 7 y; 9 M/16 F) completed familiarization and then three randomly ordered experimental visits where they consumed either 600 mg (GLE) or 1200 mg (GLE) GLE or placebo (PLA). Following supplement consumption, participants completed a mood state survey, assessments of perceived jitteriness, energy, and focus, and neurocognitive and motor-cognitive testing. Blood pressure (BP), heart rate, and QT interval length were determined before and after supplementation.
GLE significantly improved total mood disturbance (mean ± SE difference = -6.9 ± 2.6 au, = 0.034), fatigue-inertia (-2.84 ± 0.89 au, = 0.008), perceived energy (+13.00 ± 4.49 au; = 0.02), motor speed (+4.52 ± 1.42 au, = 0.008), and psychomotor speed (+7.20 ± 2.16 au, = 0.005) relative to PLA. GLE also improved psychomotor speed (+5.08 ± 2.16 ms, = 0.045) and uniquely increased motor-cognitive performance as reflected by a decrease in reaction time (-0.106 ± 0.04 ms, = 0.026) during a neurocognitive hop test. The effect of GLE on jitteriness was both dose- and sex-dependent. Jitteriness increased with increasing GLE dose in women only ( < 0.001). Both GLE and GLE similarly increased systolic and diastolic BP by 4-5 mmHg ( ≤ 0.022). Neither GLE nor GLE acutely influenced QTc length ( = 0.31).
The goal of GLE supplementation should be considered when selecting a dosing strategy. Lower dosages of GLE (e.g. 600 mg) appear to optimize cognitive and mood-related outcomes while limiting side-effects such as jitteriness in women, and higher dosages may be necessary (e.g. 1200 mg) to promote improvements in motor-cognitive performance.
我们在年轻成年人中进行了一项随机、双盲、安慰剂对照的交叉试验，以研究绿茶提取物（GLE）摄入量（600毫克与1200毫克）对情绪、认知和运动认知表现的剂量依赖性急性影响，以及其急性心血管效应。
25名成年人（平均±标准差，年龄=28±7岁；9名男性/16名女性）完成了预实验，然后进行了三次随机排序的实验访视，期间他们分别服用600毫克（GLE）或1200毫克（GLE）的GLE或安慰剂（PLA）。补充剂服用后，参与者完成了情绪状态调查、对紧张感、精力和注意力的感知评估，以及神经认知和运动认知测试。在补充前后测定血压（BP）、心率和QT间期长度。
与PLA相比，GLE显著改善了总情绪紊乱（平均±标准误差异=-6.9±2.6au，P=0.034）、疲劳-惰性（-2.84±0.89au，P=0.008）、感知精力（+13.00±4.49au；P=0.02）、运动速度（+4.52±1.42au，P=0.008）和心理运动速度（+7.20±2.16au，P=0.005）。GLE还改善了心理运动速度（+5.08±2.16毫秒，P=0.045），并独特地提高了运动认知表现，这在神经认知单脚跳测试中反应时间的减少（-0.106±0.04毫秒，P=0.026）中得到体现。GLE对紧张感的影响具有剂量和性别依赖性。仅在女性中，紧张感随GLE剂量增加而增加（P<0.001）。GLE和GLE均使收缩压和舒张压类似地升高4-5mmHg（P≤0.022）。GLE和GLE均未急性影响QTc长度（P=0.31）。
在选择给药策略时应考虑补充GLE的目标。较低剂量的GLE（例如600毫克）似乎能优化认知和情绪相关结果，同时限制女性的紧张感等副作用，而较高剂量（例如1200毫克）可能是促进运动认知表现改善所必需的。
