Milewski S, Chmara H, Borowski E
Arch Microbiol. 1986 Aug;145(3):234-40. doi: 10.1007/BF00443651.
The antibiotic tetaine inhibits in Candida albicans the biosynthesis of two important cell wall constituents, chitin and mannoprotein. This effect is a consequence of inactivation of the enzyme glucosamine-6-phosphate synthetase. Due to the lack of glucosamine-6-phosphate the effective secretion of mannoprotein enzymes, acid phosphatase and invertase, by Candida albicans spheroplasts is inhibited. In the presence of tetaine, probably a modified mannoprotein, lacking a branched polymannan, is synthesized. The antibiotic action decreases the viability of Candida albicans cells, especially that of mycelial forms of this fungus.
抗生素泰他宁可抑制白色念珠菌中两种重要细胞壁成分几丁质和甘露糖蛋白的生物合成。这种作用是6-磷酸葡糖胺合成酶失活的结果。由于缺乏6-磷酸葡糖胺，白色念珠菌原生质体对甘露糖蛋白酶、酸性磷酸酶和转化酶的有效分泌受到抑制。在泰他宁存在的情况下，可能会合成一种缺少分支多聚甘露糖的修饰甘露糖蛋白。抗生素的作用会降低白色念珠菌细胞的活力，尤其是该真菌菌丝体形态的细胞活力。
