Biotechnology Institute, School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian, 116028, China.
Institute of Molecular Plant Science, University of Edinburgh, Edinburgh, EH9 3BF, UK.
Curr Pharm Biotechnol. 2023;24(2):279-298. doi: 10.2174/1389201023666220324123926.
The medicinal properties of plants can be predicted by virtue of phylogenetic methods, which nevertheless have not been utilized to explore the regularity of skin-related bioactivities of ethnomedicinal plants. We aim to investigate the distribution of skin efficacy of Asteraceae and Ranunculales plants on the species-level Tree of Life.
The clinical efficacy data of 551 ethnomedicinal species belonging to Ranunculales, as well as 579 ethnomedicinal species of Asteraceae, were systematically collected and collated; these therapeutic data fell into 15 categories, including skin disease/cosmeceutical. The large phylogenetic tree of all China angiosperm species was used to detect the phylogenetic signals of ethnomedicinal plants by calculating the D statistic, phylogenetic diversity (PD), net relatedness index (NRI), and nearest taxon index (NTI). Of all Chinese ethnomedicinal plants of Ranunculales and Asteraceae, 339 (61.5% of all ethnomedicinal species) and 382 (66.0% of all) are used for skin problems. In Ranunculales, a clustered structure was suggested by the NRI value for skin uses. In Asteraceae, the skin utility was not clustered; Artemisia, Aster, Cremanthodium, Ligularia, and Saussurea are the most used Asteraceae genera for skin issues.
The clustering structure was identified in Artemisia, and the skin efficacy in other genera was of overdispersion (NRI < 0). NTI values and D statistics largely agree with NRI. When compared with PD values of different therapeutic categories, the PD value of the skin category was relatively high in Cremanthodium, Ranunculales, Asteraceae, and Artemisia, suggesting the enormous efficacy space in the new taxa of these taxonomic groups.
By resolving the distribution of therapeutic effects of Ranunculales/Asteraceae taxa, the importance of phylogenetic methods in mining botanical resources with skin utilities is validated.
植物的药用特性可以通过系统发育方法来预测，但尚未被用于探索民族药用植物与皮肤相关生物活性的规律。我们旨在探讨菊科和毛茛目的植物在物种水平生命之树上的皮肤功效分布。
系统地收集和整理了毛茛目和菊科的 551 种民族药用植物的临床疗效数据，以及 579 种菊科民族药用植物的临床疗效数据；这些治疗数据分为 15 类，包括皮肤病/化妆品。利用中国所有被子植物物种的大型系统发育树，通过计算 D 统计量、系统发育多样性（PD）、净亲缘关系指数（NRI）和最近分类单元指数（NTI）来检测民族药用植物的系统发育信号。在中国毛茛目和菊科的所有民族药用植物中，有 339 种（所有民族药用物种的 61.5%）和 382 种（所有民族药用物种的 66.0%）用于治疗皮肤问题。在毛茛目中，NRI 值提示了皮肤用途的聚类结构。在菊科中，皮肤用途没有聚类；蒿属、菊属、蟹甲草属、橐吾属和薊属是治疗皮肤问题最常用的菊科属。
在蒿属中鉴定出聚类结构，而其他属的皮肤功效呈过分散布（NRI<0）。NTI 值和 D 统计量与 NRI 基本一致。与不同治疗类别的 PD 值相比，Cremanthodium、毛茛目、菊科和蒿属的皮肤类 PD 值相对较高，表明这些分类群的新分类单元具有巨大的功效空间。
通过解析毛茛目/菊科分类群治疗效果的分布，验证了系统发育方法在挖掘具有皮肤功效的植物资源方面的重要性。
