Parvin Irin, Das Sumon Kumar, Ahmed Shahnawaz, Rahman Aminur, Shahid Abu Sadat Mohammad Sayeem Bin, Shahrin Lubaba, Afroze Farzana, Ackhter Mst Mahmuda, Alam Tahmina, Jahan Yasmin, Palit Parag, Sarker Mohammad Habibur Rahman, Das Jui, Hoque Mohammad Enamul, Magalhães Ricardo J Soares, Mamun Abdullah Al, Faruque Abu Syed Golam, Ahmed Tahmeed, Chisti Mohammod Jobayer
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Menzies-School of Health Research, Charles Darwin University, Darwin, NT 0811, Australia.
Pathogens. 2022 Mar 10;11(3):336. doi: 10.3390/pathogens11030336.
Gestational () infection may cause substantial adverse effects on developing fetuses, newborns and also mothers. This study aims to estimate the seroprevalence of among rural Bangladeshi pregnant women and determine the risk of a low birth weight (LBW). We followed a longitudinal design where 208 pregnant women were followed until the birth of their infants. Levels of IgG and IgM of were assessed using chemiluminescent immunoassay. Modified Poisson regression was used to estimate crude and adjusted associations and multiple regression analysis was performed to understand the confounding and modifying effects of the variables. Thirty-nine (19%) children were born with LBW, among whom 15 (39%) mothers were positive for IgG during pregnancy. After adjusting for several confounders and modifiers, pregnant women with or IgM seropositivity were significantly associated with LBW of infants (aRR: 2.00, 95% CI: 1.17-3.42). The strength of this association increased after adjusting for maternal education (aRR: 4.88, 95% CI: 1.74-13.69). The final model had an AROC of 0.84 with a sensitivity of 36% and specificity of 97%. Although causality is yet to be established, the study observed an association between infection during pregnancy among rural Bangladeshi women and LBW of newborns.
妊娠期（）感染可能会对发育中的胎儿、新生儿以及母亲造成严重的不良影响。本研究旨在估计孟加拉国农村孕妇中（）的血清阳性率，并确定低出生体重（LBW）的风险。我们采用纵向设计，对208名孕妇进行跟踪随访直至其婴儿出生。使用化学发光免疫分析法评估（）的IgG和IgM水平。采用修正泊松回归来估计粗略和调整后的关联，并进行多元回归分析以了解变量的混杂和修正效应。39名（19%）儿童出生时为低出生体重，其中15名（39%）母亲在孕期（）IgG呈阳性。在对多个混杂因素和修正因素进行调整后，（）或IgM血清阳性的孕妇与婴儿低出生体重显著相关（调整后相对危险度：2.00，95%置信区间：1.17 - 3.42）。在对母亲教育程度进行调整后，这种关联的强度增加（调整后相对危险度：4.88，95%置信区间：1.74 - 13.69）。最终模型的曲线下面积为0.84，灵敏度为36%，特异度为97%。尽管因果关系尚未确立，但该研究观察到孟加拉国农村妇女孕期（）感染与新生儿低出生体重之间存在关联。
