College of Animal Science and Technology, Guangxi University, Nanning, China.
State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China.
J Appl Microbiol. 2022 Jun;132(6):4466-4475. doi: 10.1111/jam.15545. Epub 2022 Apr 4.
Our study aimed to evaluate the effects of different dosages of sodium butyrate and niacin on the growth performance, faecal Vitamin B and microbiota in weaned piglets.
Seventy-two weaned piglets (Duroc × Landrace × Yorkshire, age of 21 days) were randomly assigned to one of six treatments (12 pigs/treatment); the control (CT) group was administered a basal diet. The groups in which concentration ratios of sodium butyrate to niacin were 100: 1, 100: 2, 100: 4, 100: 8 and 100: 16 (BN1, BN2, BN4, BN8 and BN16) were administered a basal diet supplemented with 2000 mg kg sodium butyrate and 20, 40, 80, 160 or 320 mg·kg niacin. After 14-day treatment, the samples were collected. The results showed that feed conversion rate (FCR) was reduced and average daily gain (ADG) was increased in BN2 (p < 0.05). The diarrhoea index of pigs decreased with the low supplement. Additionally, compared with the CT group, other groups significantly increased (p < 0.05) the abundance of Firmicutes (BN4, phylum), Lactobacillaceae (BN8, family), Megasphaera (BN8, genus) and Lactobacillus (BN8, genus). Furthermore, the sodium butyrate and niacin supplementation influence Vitamin B1, Vitamin B2, pyridoxine, niacin, nicotinamide and Vitamin B12 (p < 0.05). Correlation analysis of the association of micro-organisms with Vitamin B indicated that changes of Vitamin B metabolism have a potential correlation with alterations of faecal microbiota in weaned piglets.
The results indicated that adding sodium butyrate and niacin in the diet could promote the performance and improve the faecal microbiota and Vitamin B metabolism in weaned piglets.
Our study might provide clues to the research of correlations between faecal bacteria and faecal Vitamin B, and these findings will contribute to the direction of future research in weaned piglets.
本研究旨在评估不同剂量的丁酸钠和烟酰胺对断奶仔猪生长性能、粪便维生素 B 和微生物区系的影响。
72 头断奶仔猪（杜洛克×长白×约克夏，21 日龄）随机分为 6 个处理组（每组 12 头猪）；对照组（CT）给予基础日粮。丁酸钠与烟酰胺浓度比为 100:1、100:2、100:4、100:8 和 100:16（BN1、BN2、BN4、BN8 和 BN16）的组分别给予基础日粮，添加 2000mg·kg 丁酸钠和 20、40、80、160 或 320mg·kg 烟酰胺。14 天后采集样品。结果表明，BN2 组饲料转化率（FCR）降低，平均日增重（ADG）增加（p<0.05）。低添加量降低了猪的腹泻指数。此外，与 CT 组相比，其他组Firmicutes（BN4，门）、Lactobacillaceae（BN8，科）、Megasphaera（BN8，属）和 Lactobacillus（BN8，属）的丰度显著增加（p<0.05）。此外，丁酸钠和烟酰胺的补充影响维生素 B1、维生素 B2、吡哆醇、烟酰胺、烟酰胺和维生素 B12（p<0.05）。微生物与维生素 B 关联的相关性分析表明，维生素 B 代谢的变化与断奶仔猪粪便微生物区系的变化具有潜在相关性。
结果表明，在日粮中添加丁酸钠和烟酰胺可以促进断奶仔猪的生长性能，改善粪便微生物区系和维生素 B 代谢。
本研究为粪便细菌与粪便维生素 B 之间的相关性研究提供了线索，这些发现将有助于指导未来对断奶仔猪的研究。
